Ixekizumab Improves Functioning and Health in the Treatment of Radiographic Axial Spondyloarthritis: Week 52 Results from 2 Pivotal Studies.

The Journal of Rheumatology
Uta KiltzJ Braun

Abstract

This study evaluated the effect of ixekizumab (IXE) on self-reported functioning and health in patients with radiographic axial spondyloarthritis (r-axSpA) who were either biological disease-modifying antirheumatic drug (bDMARD)-naïve or failed at least 1 tumor necrosis factor inhibitor (TNFi). In 2 multicenter, randomized, double-blind, placebo-controlled, and active-controlled (bDMARD-naïve only) trials, patients with r-axSpA were randomly assigned to receive 80 mg of IXE [every 2 weeks (Q2W) or every 4 weeks (Q4W)], placebo (PBO), or adalimumab (ADA; bDMARD-naïve only). After 16 weeks, patients who received PBO or ADA were rerandomized to receive IXE (Q2W or Q4W) up to Week 52. Functioning and health were measured by the generic 36-item Short Form Health Survey (SF-36) and the disease-specific Assessment of Spondyloarthritis international Society Health Index (ASAS HI). Societal health utility was assessed by the 5-level EuroQol-5 Dimension (EQ-5D-5L). At Week 16, both doses of IXE in bDMARD-naïve and TNFi-experienced patients resulted in larger improvement in SF-36, ASAS HI, and EQ-5D-5L versus placebo. For SF-36, the largest improvements were seen for the domains of bodily pain, physical function, and role physical. A larg...Continue Reading

References

Dec 22, 2000·Spine·J E Ware
Mar 25, 2011·The American Journal of the Medical Sciences·John D Reveille
Jan 26, 2012·Arthritis Care & Research·John D ReveilleMichael H Weisman
Jun 18, 2015·Clinical and Experimental Immunology·H Jethwa, P Bowness
Dec 30, 2015·Arthritis Care & Research·Carmen StolwijkAstrid van Tubergen
Jan 1, 2015·Nature Reviews. Disease Primers·Joachim SieperDominique Baeten
Jan 15, 2017·Annals of the Rheumatic Diseases·Désirée van der HeijdeJürgen Braun
Jan 24, 2017·Lancet·Joachim Sieper, Denis Poddubnyy
Sep 25, 2017·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Vibeke Strand, Jasvinder A Singh
Dec 1, 2017·Expert Opinion on Biological Therapy·Eric Toussirot
Apr 9, 2019·Expert Opinion on Biological Therapy·Murat Torgutalp, Denis Poddubnyy

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