PMID: 11322030Apr 27, 2001Paper

J-curve between alcohol consumption and carotid atherosclerosis in patients with dyslipidemia

Anales de medicina interna : organo oficial de la Sociedad Española de Medicina Interna
J M SilvaE Pinto

Abstract

Cerebrovascular disease is the leading cause of death in Portugal and carotid disease is responsible for 20 to 50% of strokes. As dyslipidaemias and alcoholism are frequent problems in our country, we planned to examine the relationship of alcohol consumption and carotid disease in dyslipidaemic patients, a subject that has never been specifically studied, as far as we know. We studied 102 dyslipidaemic patients, 38 females and 64 males. We used the following classification for echo-doppler results; grade 0--normal; grade 1--intimal-medial thickening (> or = 1 mm); grade 2--one plaque; grade 3--two or more plaques; grade 4--haemodynamic disturbance. We measured several biochemical and clinical parameters, including declared alcohol consumption. In a stepwise regression we found that age had the highest correlation with carotid atherosclerosis, followed by alcohol consumption. Visually we noticed a J-curve between alcohol consumption and carotid atherosclerosis, that we confirmed with a polynomial regression (r = 0.318, p = 0.0114). Carotid atherosclerosis increased only with levels of alcohol consumption over 60 g/day, in spite of even lower levels of alcohol consumption being associated with lower HDL-C and higher triglyceride...Continue Reading

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