J-refocused coherence transfer spectroscopic imaging at 7 T in human brain.

Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine
J W PanHoby P Hetherington

Abstract

Short echo spectroscopy is commonly used to minimize signal modulation due to J-evolution of the cerebral amino acids. However, short echo acquisitions suffer from high sensitivity to macromolecules which make accurate baseline determination difficult. In this report, we describe implementation at 7 T of a double echo J-refocused coherence transfer sequence at echo time (TE) of 34 msec to minimize J-modulation of amino acids while also decreasing interfering macromolecule signals. Simulation of the pulse sequence at 7 T shows excellent resolution of glutamate, glutamine, and N-acetyl aspartate. B(1) sufficiency at 7 T for the double echo acquisition is achieved using a transceiver array with radiofrequency (RF) shimming. Using an alternate RF distribution to minimize receiver phase cancellation in the transceiver, accurate phase determination for the coherence transfer is achieved with rapid single scan calibration. This method is demonstrated in spectroscopic imaging mode with n = 5 healthy volunteers resulting in metabolite values consistent with literature and in a patient with epilepsy.

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Citations

Feb 27, 2014·Radiology·Gülin OzUNKNOWN MRS Consensus Group
Jun 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Abhishek BanerjeeChangho Choi
Feb 27, 2013·NMR in Biomedicine·X ChenA Henning
Jun 14, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·He ZhuPeter B Barker
Nov 22, 2011·NMR in Biomedicine·Ewald MoserSiegfried Trattnig
Jan 4, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Anna AndreychenkoDennis W J Klomp
Apr 17, 2012·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·J W PanH P Hetherington
Nov 22, 2014·Frontiers in Human Neuroscience·Birgit R PlantingaBart M Ter Haar Romenij
Feb 16, 2018·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Vivek TiwariChangho Choi
Jul 22, 2014·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Sigrun GoluchElmar Laistler
Dec 17, 2015·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Yanqin LinZhong Chen
Jul 14, 2019·Epilepsy & Behavior : E&B·Carlo RondinoniEdson Amaro
Dec 5, 2020·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Gonzalo M QuiñonesFabio Ferrarelli

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