J Waves for Predicting Cardiac Events in Hypertrophic Cardiomyopathy

JACC. Clinical Electrophysiology
Toyonobu TsudaMasakazu Yamagishi

Abstract

This study sought to investigate whether the presence of J waves was associated with cardiac events in patients with hypertrophic cardiomyopathy (HCM). It has been uncertain whether the presence of J waves predicts life-threatening cardiac events in patients with HCM. This study evaluated consecutive 338 patients with HCM (207 men; age 61 ± 17 years of age). A J-wave was defined as J-point elevation >0.1 mV in at least 2 contiguous inferior and/or lateral leads. Cardiac events were defined as sudden cardiac death, ventricular fibrillation or sustained ventricular tachycardia, or appropriate implantable cardiac defibrillator therapy. The study also investigated whether adding the J-wave in a conventional risk model improved a prediction of cardiac events. J waves were seen in 46 (13.6%) patients at registration. Cardiac events occurred in 31 patients (9.2%) during median follow-up of 4.9 years (interquartile range: 2.6 to 7.1 years). In a Cox proportional hazards model, the presence of J waves was significantly associated with cardiac events (adjusted hazard ratio: 4.01; 95% confidence interval [CI]: 1.78 to 9.05; p = 0.001). Compared with the conventional risk model, the model using J waves in addition to conventional risks bet...Continue Reading

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Citations

Mar 10, 2020·Journal of the American Heart Association·Satoshi HiguchiNobuhisa Hagiwara
Feb 1, 2018·Journal of the Endocrine Society·Shigehiro KarashimaTakashi Yoneda
Jun 1, 2021·The Journal of Veterinary Medical Science·Samar H Elsharkawy, Faisal A Torad
Nov 6, 2018·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Michel HaïssaguerreOlivier Bernus
Feb 6, 2020·Cardiology·Pedro Miguel Oliveira AzevedoJosé Braga

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