Jaagsiekte sheep retrovirus is present at high concentration in lung fluid produced by ovine pulmonary adenocarcinoma-affected sheep and can survive for several weeks at ambient temperatures

Research in Veterinary Science
Christina CousensDavid J Griffiths

Abstract

Jaagsiekte sheep retrovirus (JSRV) causes a fatal lung cancer of sheep known as ovine pulmonary adenocarcinoma (OPA). OPA is a significant disease in many sheep-rearing countries and there is no effective method of control. A unique feature of OPA is the overproduction of fluid in the lung of affected animals. This lung fluid contains JSRV and provides a means of transmission through the inhalation of virus. In this study we demonstrated that lung fluid from different OPA cases contained between 10(7) and 10(10) copies of JSRV RNA per ml. Examination of JSRV RNA survival under conditions that mimic natural conditions suggested that intact JSRV virions may persist for several weeks in the environment. These are the first quantitative data on JSRV in lung fluid and provide valuable information for implementing appropriate biosecurity measures to control the spread of JSRV in the field.

Citations

Apr 30, 2013·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Esther Humann-ZiehankMartin Ganter
Feb 19, 2010·Journal of Comparative Pathology·D J GriffithsC Cousens
Aug 2, 2014·International Journal of Cancer. Journal International Du Cancer·Dariush NasrollahzadehReza Malekzadeh
Jul 5, 2011·Environmental Research·Eric S JohnsonRaquel Qualls-Hampton
May 21, 2015·ILAR Journal·Gehad YoussefDavid J Griffiths
Apr 19, 2015·Retrovirology·Chris CousensDavid J Griffiths
Feb 7, 2015·Environment International·E S JohnsonA Katyal
Jan 29, 2011·Journal of Virology·Henny M MartineauDavid J Griffiths
Dec 31, 2019·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Hanne Jahns, Chris Cousens
Aug 23, 2019·Journal of Virology·Anna Eleonora KaragianniDavid J Griffiths
May 21, 2019·Frontiers in Oncology·Mark E GrayDavid Argyle
Oct 31, 2020·Vector Borne and Zoonotic Diseases·Halie K MillerM Constanza Camargo
Feb 7, 2021·Animals : an Open Access Journal From MDPI·Marcelo De Las HerasAurora Ortín

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