Jackhammer esophagus: Clinical presentation, manometric diagnosis, and therapeutic results-Results from a multicenter French cohort.

Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society
Sara PhilonenkoBenoit Coffin

Abstract

Jackhammer esophagus (JE) is a hypercontractile esophageal motor disorder defined by at least two swallows with a distal contractile integral (DCI) >8000 mm Hg.s.cm during high-resolution manometry (HRM). The relationship between symptoms and hypercontractility and the response to therapies have been poorly evaluated. The aim of this study was to determine the clinical presentation, manometric diagnosis, and therapeutic results in a large cohort of JE patients. Patients with JE diagnosed among the HRM tests performed in nine academic French centers from 01/01/2010 to 08/31/2016 were included. Patient charts were reviewed to collect clinical and therapeutic data. Among the 16 264 HRM tests performed during this period, 227 patients (60.8 ± 13.8 years, 151 male) had JE (1.7%). Dysphagia was the most frequent symptom (74.6%), followed by regurgitation (37.1%) and chest pain (36.6%); 4.7% of the patients were asymptomatic. The diagnostic workup was heterogeneous, and only a minority of patients had esophageal biopsies. None of the individual symptoms were significantly associated with any of the manometric parameters defined, except for dysphagia, which was significantly associated with the mean of all DCIs >8000 mm Hg.s.cm (P = .0...Continue Reading

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Citations

Dec 30, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Rena YadlapatiJohn E Pandolfino
Dec 5, 2020·The American Journal of Gastroenterology·Nicola de BortoliEdoardo Vincenzo Savarino
Mar 18, 2021·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Joan W ChenCharles Cock
Nov 14, 2020·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·Arash BabaeiBenson T Massey
Oct 14, 2021·Journal of Neurogastroenterology and Motility·Yinglian XiaoJohn E Pandolfino
Jan 5, 2022·Journal of Neurogastroenterology and Motility·Alex Ju Sung KimDae Young Hur

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