JAK2(V617F) allele burden in polycythemia vera correlates with grade of myelofibrosis, but is not substantially affected by therapy.

Leukemia Research
Richard T SilverNicholas C P Cross

Abstract

In a series of 105 patients with polycythemia vera, we retrospectively determined whether the JAK2(V617F) mutation correlated with severity of disease phenotype. Higher JAK2(V617F) allele burden correlated with more advanced myelofibrosis, greater splenomegaly, and higher white blood cell count, but not with age, gender, hematocrit level, or frequency of phlebotomy prior to cytoreductive therapy. Although a subgroup at increased risk for thrombosis was not clearly defined, there was a suggestion that frequency of thrombosis increased as the JAK2(V617F) allele burden increased. The JAK2(V617F) allele burden did not change significantly in treated patients with serial JAK2 analyses.

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Citations

Mar 29, 2014·International Journal of Hematology·Yoko EdahiroNorio Komatsu
Oct 4, 2014·Blood·Alessandro M Vannucchi
Dec 19, 2012·Leukemia & Lymphoma·Brady L SteinAlison R Moliterno
Apr 25, 2012·Leukemia & Lymphoma·Maya Koren-MichowitzArnon Nagler
May 23, 2012·Blood·Francesco Passamonti
Oct 1, 2016·American Journal of Clinical Pathology·Lambert BusqueVikas Gupta
Nov 19, 2013·Clinical Lymphoma, Myeloma & Leukemia·Hagop M KantarjianClaire N Harrison
Apr 24, 2013·Therapeutic Advances in Hematology·Mohamad Bassam SonbolRamon V Tiu
Sep 19, 2019·Médecine sciences : M/S·Alexandre Guy, Chloé James
Jun 24, 2017·Current Protocols in Pharmacology·Andrew DunbarRoss Levine
Feb 5, 2013·Expert Review of Hematology·Richard T SilverHans Carl Hasselbalch
May 5, 2020·Frontiers in Physiology·Patrick LilienthalSebastian Sager

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