Janus electrochemistry: Simultaneous electrochemical detection at multiple working conditions in a paper-based analytical device

Analytica Chimica Acta
Siriwan NantapholCharles S Henry

Abstract

The simultaneous detection of multiple analytes from a single sample is a critical tool for the analysis of real world samples. However, this is challenging to accomplish in the field by current electroanalytical techniques, where tuning assay conditions towards a target analyte often results in poor selectivity and sensitivity for other species in the mixture. In this work, an electrochemical paper-based analytical device (ePAD) capable of performing simultaneous electrochemical experiments in different solution conditions on a single sample was developed for the first time. We refer to the system as a Janus-ePAD after the two-faced Greek god because of the ability of the device to perform electrochemistry on the same sample under differing solution conditions at the same time with a single potentiostat. In a Janus-ePAD, a sample wicks down two channels from a single inlet towards two discreet reagent zones that adjust solution conditions, such as pH, before flow termination in two electrochemical detection zones. These zones feature independent working electrodes and shared reference and counter electrodes, facilitating simultaneous detection of multiple species at each species' optimal solution condition. The device utility ...Continue Reading

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Citations

Oct 16, 2019·Electrophoresis·Worapot Suntornsuk, Leena Suntornsuk
May 18, 2020·Biosensors·Alberto Sánchez-CalvoAgustín Costa-García
Jul 1, 2020·Journal of Forensic Sciences·Maria Fernanda M RibeiroMarcelo F de Oliveira
Jul 2, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Siraprapa BoobphahomKwanwoo Shin
Sep 16, 2020·Analytical Methods : Advancing Methods and Applications·M C Díaz-LiñánA I López-Lorente
May 12, 2020·Analytica Chimica Acta·Eka NovianaCharles S Henry
Jun 15, 2021·Chemical Reviews·Eka NovianaCharles S Henry
Dec 11, 2019·Analytical Chemistry·Jaruwan MettakoonpitakCharles S Henry

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