Janus nanocarrier powered by bi-enzymatic cascade system for smart delivery

Journal of Materials Chemistry. B, Materials for Biology and Medicine
Sandra Jimenez-FalcaoReynaldo Villalonga

Abstract

We report herein the assembly of an integrated nanodevice with bi-enzymatic cascade control for on-command cargo release. This nanocarrier is based on Au-mesoporous silica Janus nanoparticles capped at the mesoporous face with benzimidazole/β-cyclodextrin-glucose oxidase pH-sensitive gate-like ensembles and functionalized with invertase on the gold face. The rationale for this delivery mechanism is based on the invertase-mediated hydrolysis of sucrose yielding glucose, which is further transformed into gluconic acid by glucose oxidase causing the disruption of the pH-sensitive supramolecular gates at the Janus nanoparticles. This enzyme-powered device was successfully employed in the autonomous and on-demand delivery of doxorubicin in HeLa cancer cells.

References

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Citations

May 13, 2020·Chemical Communications : Chem Comm·Ana M Pérez-CalabuigReynaldo Villalonga
Sep 29, 2020·Chemphyschem : a European Journal of Chemical Physics and Physical Chemistry·Sucheta BanerjeeAnindya Datta
May 11, 2021·Applied Microbiology and Biotechnology·Mandeep DixitPratyoosh Shukla

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Methods Mentioned

BETA
X-ray
confocal microscopy

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