Japanese and North American Alzheimer's Disease Neuroimaging Initiative studies: Harmonization for international trials

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Takeshi IwatsuboAlzheimer's Disease Neuroimaging Initiative

Abstract

We conducted Japanese Alzheimer's Disease Neuroimaging Initiative (J-ADNI) and compared the basic characteristics and progression profiles with those of ADNI in North America. A total of 537 Japanese subjects with normal cognition, late amnestic mild cognitive impairment (LMCI), or mild Alzheimer's disease (AD) were enrolled using the same criteria as ADNI. Rates of changes in representative cognitive or functional measures were compared for amyloid positron emission tomography- or cerebrospinal fluid amyloid β(1-42)-positive LMCI and mild AD between J-ADNI and ADNI. Amyloid positivity rates were significantly higher in normal cognition of ADNI but at similar levels in LMCI and mild AD between J-ADNI and ADNI. Profiles of decline in cognitive or functional measures in amyloid-positive LMCI in J-ADNI (n = 75) and ADNI (n = 269) were remarkably similar, whereas those in mild AD were milder in J-ADNI (n = 73) compared with ADNI (n = 230). These results support the feasibility of bridging of clinical trials in the prodromal stage of AD between Asia and western countries.

References

Apr 6, 1999·Archives of Neurology·R C PetersenE Kokmen
Apr 23, 2003·Biological Psychiatry·Craig H MallinckrodtGary D Tollefson
Mar 25, 2004·Lancet Neurology·Bruno Dubois, Martin L Albert
Mar 20, 2009·Annals of Neurology·Leslie M ShawUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Oct 14, 2009·Neurology·W J JagustUNKNOWN Alzheimer's Disease Neuroimaging Initiative
May 11, 2011·Contemporary Clinical Trials·M C DonohueUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Nov 6, 2012·Cold Spring Harbor Perspectives in Medicine·David M HoltzmanDennis J Selkoe
Nov 21, 2012·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Susan M LandauUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 29, 2013·Annals of Neurology·Susan M LandauUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 30, 2013·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Niklas MattssonUNKNOWN Alzheimer's Association QC Program Work Group
Jul 26, 2013·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Semagacestat Study Group
Dec 24, 2013·Neuron·Clifford R Jack, David M Holtzman
Jan 24, 2014·The New England Journal of Medicine·Rachelle S DoodyUNKNOWN Solanezumab Study Group
Jan 24, 2014·The New England Journal of Medicine·Stephen SallowayUNKNOWN Bapineuzumab 301 and 302 Clinical Trial Investigators
Mar 22, 2014·Science Translational Medicine·Reisa A SperlingPaul Aisen
Apr 26, 2014·Journal of Alzheimer's Disease : JAD·Akinori MiyashitaRyozo Kuwano
Aug 2, 2014·Expert Review of Neurotherapeutics·Francesco PanzaGiancarlo Logroscino
Sep 2, 2016·Nature·Jeff SevignyAlfred Sandrock
Dec 3, 2016·Journal of Alzheimer's Disease : JAD·Motonobu FujishimaUNKNOWN Japanese Alzheimer’s Disease Neuroimaging Initiative (J-ADNI)
Mar 28, 2017·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Michael W WeinerUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Citations

Aug 24, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Takuya YagiUNKNOWN Japanese Alzheimer's Disease Neuroimaging Initiative
Jan 22, 2019·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Atsushi IwataUNKNOWN Japanese Alzheimer’s Disease Neuroimaging Initiative
Nov 22, 2019·Annals of Nuclear Medicine·Yusuke OkadaUNKNOWN Japanese Alzheimer’s Disease Neuroimaging Initiative
Dec 5, 2018·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Ryoko IharaUNKNOWN Japanese Alzheimer's Disease Neuroimaging Initiative
May 12, 2020·Journal of Alzheimer's Disease : JAD·Claude RobertCharles-Daniel Arreto
Jun 15, 2020·Psychiatry and Clinical Neurosciences·Yasuharu YamamotoBun Yamagata
Sep 8, 2019·Japanese Journal of Radiology·Hiroshi MatsudaNoriko Sato
Sep 20, 2019·EJNMMI Research·Go AkamatsuUNKNOWN Japanese Alzheimer’s Disease Neuroimaging Initiative
Mar 27, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Kazushi SuzukiUNKNOWN Alzheimer's Disease Neuroimaging Initiative, Japanese Alzheimer's Disease Neuroimaging Initiative
Jun 15, 2020·Annals of Nuclear Medicine·Natsumi ShimokawaMasayuki Sasaki
Mar 1, 2019·Journal of Alzheimer's Disease : JAD·Kenichiro SatoUNKNOWN Alzheimer’s Disease Neuroimaging Initiative, and Japanese Alzheimer’s Disease Neuroimaging Initiative
Jan 4, 2019·Annals of Nuclear Medicine·Kenji IshibashiUNKNOWN J-ADNI Study Group
Dec 22, 2020·Frontiers in Aging Neuroscience·Yasuharu YamamotoMasaru Mimura
Dec 22, 2020·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Colin BirkenbihlUNKNOWN and the Alzheimer's Disease Neuroimaging Initiative
Mar 21, 2021·NeuroImage. Clinical·Shinsuke KoikeUNKNOWN Brain/MINDS Beyond Human Brain MRI Group
Mar 30, 2021·Alzheimer's & Dementia : Translational Research & Clinical Interventions·Kenichiro SatoTakeshi Iwatsubo
May 28, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Harald HampelAndrea Vergallo
Jun 11, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Colin BirkenbihlUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Sep 29, 2021·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Dallas P VeitchUNKNOWN Alzheimer's Disease Neuroimaging Initiative

❮ Previous
Next ❯

Related Concepts

Related Feeds

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Alzheimer's Disease: APP

Amyloid precursor protein (APP) proteolysis is critical for the development of Alzheimer's disease, a neurodegenerative disease associated with accumulation of amyloid plaques in the brain. Here is the latest research on APP and Alzheimer's disease.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Related Papers

Alzheimer's & Dementia : the Journal of the Alzheimer's Association
William JagustAlzheimer's Disease Neuroimaging Initiative
Alzheimer's & Dementia : the Journal of the Alzheimer's Association
Jasmine NettiksimmonsAlzheimer's Disease Neuroimaging Initiative
Current Alzheimer Research
Richard E KennedyAlzheimer's Disease Neuroimaging Initiative
© 2022 Meta ULC. All rights reserved