Japanese encephalitis - serial CT findings and neuropathology in an autopsy case

Clinical Neuropathology
Z KobayashiH Mizusawa

Abstract

The patient was a 17-year-old man, who developed Japanese encephalitis in the autumn of 1990 in Japan. He was admitted to our hospital 4 days after onset because of consciousness disturbance. On admission, neurological examination demonstrated left hemiparesis, neck stiffness, and Kernig's sign. He developed generalized tonico-clonic seizure, and required a respirator on the next day of admission. Brain CT 10 days after onset demonstrated hypodensities in the right hippocampus, and the CT obtained 39 days after onset showed whole brain atrophy and hypodensities in the anterior portion of the bilateral thalamus. He died 40 days after onset. Postmortem examination demonstrated perivascular and parenchymal infiltration of lymphocytes and macrophages, proliferation of microglia and astrocytes, and necrosis in the gray matter of the brain. Involvement of the hippocampus and thalamus on CT seemed to reflect the severe lesions characterized by cellular infiltration and necrosis. We discussed for the first time the correlation of CT and neuropathological findings in a patient with Japanese encephalitis.

Citations

Mar 23, 2011·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Arshed NazmiAnirban Basu
Sep 30, 2015·BMC Microbiology·Veridiana Ester BarrosVictor Hugo Aquino

❮ Previous
Next ❯

Related Concepts

Related Feeds

Astrocytes

Astrocytes are glial cells that support the blood-brain barrier, facilitate neurotransmission, provide nutrients to neurons, and help repair damaged nervous tissues. Here is the latest research.

Related Papers

Rinshō shinkeigaku = Clinical neurology
T AdachiS Onozuka
Rinshō shinkeigaku = Clinical neurology
Shinobu TanoKoichi Okamoto
Rinshō shinkeigaku = Clinical neurology
Chiharu YasudaYasuo Kuroda
Revue neurologique
P CastaigneC Duyckaerts
© 2022 Meta ULC. All rights reserved