Japanese Encephalitis Virus in Australia: From Known Known to Known Unknown

Tropical Medicine and Infectious Disease
A F van den HurkS A Ritchie

Abstract

Japanese encephalitis virus (JEV) is a major cause of neurological disease in Asia. It is a zoonotic flavivirus transmitted between water birds and/or pigs by Culex mosquitoes; humans are dead-end hosts. In 1995, JEV emerged for the first time in northern Australia causing an unprecedented outbreak in the Torres Strait. In this article, we revisit the history of JEV in Australia and describe investigations of JEV transmission cycles in the Australian context. Public health responses to the incipient outbreak included vaccination and sentinel pig surveillance programs. Virus isolation and vector competence experiments incriminated Culex annulirostris as the likely regional vector. The role this species plays in transmission cycles depends on the availability of domestic pigs as a blood source. Experimental evidence suggests that native animals are relatively poor amplifying hosts of JEV. The persistence and predominantly annual virus activity between 1995 and 2005 suggested that JEV had become endemic in the Torres Strait. However, active surveillance was discontinued at the end of 2005, so the status of JEV in northern Australia is unknown. Novel mosquito-based surveillance systems provide a means to investigate whether JEV sti...Continue Reading

References

Jul 5, 1975·The Medical Journal of Australia·K Fleming
Mar 20, 1989·The Medical Journal of Australia·W B MacdonaldR A Hawkes
Dec 1, 1983·The Australian Journal of Experimental Biology and Medical Science·D B BoyleI D Marshall
Sep 2, 1996·The Medical Journal of Australia·J N HannaP J Mills
Jan 1, 1997·The American Journal of Tropical Medicine and Hygiene·S A RitchieA van den Hurk
Jul 9, 1999·The Medical Journal of Australia·J N HannaJ S Mackenzie
Nov 6, 2001·The American Journal of Tropical Medicine and Hygiene·D T WilliamsJ S Mackenzie
Dec 19, 2001·Emerging Infectious Diseases·S A Ritchie, W Rochester
Jan 17, 2002·The American Journal of Tropical Medicine and Hygiene·A T PykeJ S Mackenzie
Jun 27, 2002·Current Topics in Microbiology and Immunology·J S MackenzieR A Hall
Feb 25, 2003·Journal of Medical Entomology·A F van den HurkS A Ritchie
Sep 7, 2004·The Medical Journal of Australia·Joshua P HansonCraig S Boutlis
Oct 6, 2007·Journal of Medical Entomology·Andrew F van den HurkScott A Ritchie
Nov 4, 2008·Emerging Infectious Diseases·Andrew F van-den-HurkGreg A Smith
Dec 11, 2008·Annual Review of Entomology·Andrew F van den HurkJohn S Mackenzie
Jun 11, 2010·Proceedings of the National Academy of Sciences of the United States of America·Sonja Hall-MendelinAndrew F van den Hurk
Nov 16, 2011·Bulletin of the World Health Organization·Grant L CampbellAmy S Ginsburg
Apr 13, 2012·Journal of Medical Entomology·Sonja Hall-MendelinAndrew F Van den Hurk
Aug 14, 2012·Current Topics in Microbiology and Immunology·Daniel E ImpoinvilTom Solomon
Feb 23, 2013·Journal of Medical Entomology·Scott A RitchieAndrew F Van Den Hurk
Dec 24, 2013·Vector Borne and Zoonotic Diseases·Andrew F van den HurkScott A Ritchie
Oct 9, 2015·Parasites & Vectors·Brian J JohnsonScott A Ritchie
Feb 24, 2016·Nature Communications·Meret E RicklinArtur Summerfield
Apr 19, 2016·Emerging Infectious Diseases·Bixing HuangDavid Warrilow
Oct 19, 2017·Transactions of the Royal Society of Tropical Medicine and Hygiene·John S MackenzieAllison Imrie

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Methods Mentioned

BETA
enzyme linked immunosorbent assay
genotyping
PCR

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