Japanese mushroom consumption alters the lipid metabolomic profile of high-fat diet-fed mice

Heliyon
Takamitsu ShimizuTsuyoshi Tsuduki

Abstract

Mushrooms are familiar ingredients in Japanese cuisine and large numbers are consumed in Japan. Recently, we reported that the consumption of Japanese mushrooms suppressed the accumulation of visceral fat. The purpose of this study was to examine the alteration of lipid metabolism by Japanese mushrooms consumption in high-fat diet (HFD) mice. Multivariate analysis of serum, liver, adipose tissue, cecal contents, large intestinal and fecal lipids showed differing compositions in the mice that had consumed HFD or HFD supplemented with 3% freeze-dried mushroom mixture (HFMD). There were higher concentrations of diacylglycerol in the adipose tissue, non-esterified fatty acids in the serum, and triacylglycerol in the feces of the HFMD group. These results suggest that mushroom consumption promotes the degradation of lipids in visceral fat and limits the absorption of food lipids. Moreover, the HFMD group demonstrated higher concentrations of phospholipids, some of which contained odd-chain fatty acids. Thus, we speculated that the alteration of lipid metabolism in mice such that mushroom consumption prevent obesity progression, as demonstrated by metabolomic analysis.

References

Jun 1, 1982·Digestive Diseases and Sciences·C Tasman-JonesA L Jones
Aug 14, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·K G Hofbauer
Oct 16, 2002·Journal of Psychosomatic Research·Myles S FaithMarie A Jorge
Apr 14, 2007·The Journal of Pharmacy and Pharmacology·Lei HongWu Wutong
Apr 1, 2010·Journal of Nutritional Science and Vitaminology·Tomohiro MizutaniEi Kawahara
Apr 9, 2010·Nature Medicine·Derek M Erion, Gerald I Shulman
Aug 10, 2010·Biochimica Et Biophysica Acta·Sa'ad H Al-LahhamKoen Venema
Nov 5, 2010·Journal of Proteome Research·Hyun-Jin KimSuk Hoo Yoon
Oct 5, 2012·Cancer Prevention Research·Stephen D HurstingNathan A Berger
Sep 25, 2014·BioMed Research International·Ming-Yei YehLi-Yun Lin
May 23, 2015·Journal of Nutritional Science and Vitaminology·Takujiro IuchiTakuya Awata
Jul 15, 2015·Current Opinion in Clinical Nutrition and Metabolic Care·E Angela MurphyKyle M Herbert
Oct 28, 2017·The Journal of Nutritional Biochemistry·Miso NamGeum-Sook Hwang
Jul 11, 2019·Journal of Proteome Research·Sara AnjosM Rosário M Domingues

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