Jarid2 and PRC2, partners in regulating gene expression.

Genes & Development
Gang LiDanny Reinberg

Abstract

The Polycomb group proteins foster gene repression profiles required for proper development and unimpaired adulthood, and comprise the components of the Polycomb-Repressive Complex 2 (PRC2) including the histone H3 Lys 27 (H3K27) methyltransferase Ezh2. How mammalian PRC2 accesses chromatin is unclear. We found that Jarid2 associates with PRC2 and stimulates its enzymatic activity in vitro. Jarid2 contains a Jumonji C domain, but is devoid of detectable histone demethylase activity. Instead, its artificial recruitment to a promoter in vivo resulted in corecruitment of PRC2 with resultant increased levels of di- and trimethylation of H3K27 (H3K27me2/3). Jarid2 colocalizes with Ezh2 and MTF2, a homolog of Drosophila Pcl, at endogenous genes in embryonic stem (ES) cells. Jarid2 can bind DNA and its recruitment in ES cells is interdependent with that of PRC2, as Jarid2 knockdown reduced PRC2 at its target promoters, and ES cells devoid of the PRC2 component EED are deficient in Jarid2 promoter access. In addition to the well-documented defects in embryonic viability upon down-regulation of Jarid2, ES cell differentiation is impaired, as is Oct4 silencing.

References

May 15, 1995·Genes & Development·T TakeuchiT Higashinakagawa
Feb 1, 1997·Methods : a Companion to Methods in Enzymology·V OrlandoR Paro
May 16, 2000·Circulation Research·Y LeeG E Lyons
Jan 10, 2002·Genesis : the Journal of Genetics and Development·E M Morin-KensickiT Magnuson
Jul 11, 2003·Developmental Cell·Masashi ToyodaTakashi Takeuchi
Aug 2, 2003·The Journal of Biological Chemistry·Tae-Gyun KimYoungsook Lee
Dec 8, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Jooyoung JungYoungsook Lee
Jan 11, 2005·Nucleic Acids Research·Antonia PatsialouElizabeth Moran
Mar 2, 2005·Biochemical and Biophysical Research Communications·Tae-gyun KimYoungsook Lee
May 5, 2005·The Journal of Biological Chemistry·Jooyoung JungYoungsook Lee
Apr 19, 2006·Genes & Development·Adrian P BrackenKristian Helin
May 23, 2006·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Takashi TakeuchiShunzo Kondo
May 30, 2006·Nature Genetics·Yuri B SchwartzVincenzo Pirrotta
Jun 6, 2006·Genome Research·Sharon L SquazzoPeggy J Farnham
Sep 21, 2006·Nature Reviews. Genetics·Robert J KloseYi Zhang
Mar 7, 2007·Molecular and Cellular Biology·Diego PasiniKristian Helin
May 25, 2007·FEBS Letters·Matthew Robert MysliwiecYoungsook Lee
Jul 3, 2007·Nature·Tarjei S MikkelsenBradley E Bernstein
Dec 19, 2007·Molecular and Cellular Biology·Ru CaoYi Zhang
Feb 21, 2008·Molecular and Cellular Biology·Kavitha SarmaDanny Reinberg
May 30, 2008·Nature·Tarjei S MikkelsenAlexander Meissner
Nov 18, 2008·The Journal of Biological Chemistry·Haruki ShiratoTakashi Takeuchi
Nov 26, 2008·Molecular Cell·Raphael MargueronDanny Reinberg
Jan 16, 2009·PLoS Biology·Bernd SchuettengruberGiacomo Cavalli
Mar 19, 2009·Nucleic Acids Research·Hana KimJoomyeong Kim
Sep 10, 2009·Nature Reviews. Molecular Cell Biology·Jeffrey A Simon, Robert E Kingston
Sep 22, 2009·Nature·Raphael MargueronSteven J Gamblin

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Citations

Feb 22, 2012·Chromosoma·M Maggie O'Meara, Jeffrey A Simon
Mar 20, 2012·Chromosoma·Martin Leeb, Anton Wutz
Jun 24, 2010·Cell Stem Cell·Aviva Presser AidenBradley E Bernstein
Nov 3, 2010·Cell Stem Cell·María J BarreroJuan Carlos Izpisúa Belmonte
Jan 21, 2011·Nature·Raphaël Margueron, Danny Reinberg
Oct 15, 2010·Nature Biotechnology·Alexander Meissner
May 5, 2011·Nature Cell Biology·Huck-Hui Ng, M Azim Surani
Nov 13, 2013·Nature Reviews. Genetics·Yuri B Schwartz, Vincenzo Pirrotta
Dec 24, 2010·Nature Reviews. Molecular Cell Biology·Alexandre Gaspar-MaiaMiguel Ramalho-Santos
May 24, 2013·Nature Reviews. Molecular Cell Biology·Tom H Cheung, Thomas A Rando
Jun 5, 2012·Nature Structural & Molecular Biology·Sònia GuilManel Esteller
Nov 13, 2012·Nature Structural & Molecular Biology·Catherine A MusselmanTatiana G Kutateladze
Oct 8, 2013·Nature Structural & Molecular Biology·Luciano Di Croce, Kristian Helin
Oct 22, 2013·Nature Structural & Molecular Biology·Syuzo KanekoRoberto Bonasio
Sep 21, 2010·Integrative Biology : Quantitative Biosciences From Nano to Macro·Xinyue Zhang, Jing Huang
Sep 7, 2012·The Journal of Biological Chemistry·Camille SindhuAlexander Meissner
Oct 27, 2010·The Journal of Experimental Medicine·Nicolaj Strøyer Christophersen, Kristian Helin
May 23, 2013·Omics : a Journal of Integrative Biology·Shahram GolbabapourA Hamid A Hadi
Feb 18, 2011·Briefings in Functional Genomics·Paul Delgado-Olguín, Félix Recillas-Targa
Mar 5, 2011·Cardiovascular Research·Kisho Ohtani, Stefanie Dimmeler
Jul 5, 2011·Nucleic Acids Research·Keunsoo KangDaeyoup Lee
May 16, 2012·Nucleic Acids Research·Kostas PaschosMartin J Allday
May 5, 2010·Genes & Development·Hans-Martin Herz, Ali Shilatifard
Nov 16, 2012·Genes & Development·David B BeckDanny Reinberg
Jun 22, 2013·Genes & Development·Philipp VoigtDanny Reinberg
Aug 22, 2013·Genes & Development·Rab Prinjha, Alexander Tarakhovsky
Apr 20, 2011·Cold Spring Harbor Symposia on Quantitative Biology·D B BeckD Reinberg
Jul 10, 2010·Science·Miao-Chih TsaiHoward Y Chang
Jun 19, 2013·Molecular and Cellular Biology·Caroline J WooRobert E Kingston
Feb 5, 2011·Circulation Research·Pei HanChing-Pin Chang
Dec 24, 2010·Journal of Dental Research·D Bayarsaihan
Nov 1, 2013·Cell & Bioscience·Lama Tarayrah, Xin Chen
May 6, 2011·Stem Cell Research & Therapy·F Jeffrey Dilworth, Alexandre Blais

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