Jasmonic acid/ethylene signaling coordinates hydroxycinnamic acid amides biosynthesis through ORA59 transcription factor

The Plant Journal : for Cell and Molecular Biology
Jinbo LiMeiliang Zhou

Abstract

Hydroxycinnamic acid amides (HCAAs) are a class of antimicrobial metabolites involved in plant defense against necrotrophic pathogens, including Alternaria brassicicola and Botrytis cinerea. The agmatine coumaryl transferase (AtACT) is the key enzyme that catalyzes the last reaction in the biosynthesis of HCAAs, including p-coumaroylagmatine (CouAgm) and feruloylagmatine in Arabidopsis thaliana. However, the regulatory mechanism of AtACT gene expression is currently unknown. Yeast one-hybrid screening using the AtACT promoter as bait isolated the key positive regulator ORA59 that is involved in jasmonic acid/ethylene (JA/ET)-mediated plant defense responses. AtACT gene expression and HCAAs biosynthesis were synergistically induced by a combination of JA and ET. In the AtACT promoter, two GCC-boxes function equivalently for trans-activation by ORA59 in Arabidopsis protoplasts, and mutation of either GCC-box abolished AtACT mRNA accumulation in transgenic plants. Site-directed mutation analysis demonstrated that the specific Leu residue at position 228 of the ORA59 EDLL motif mainly contributed to its transcriptional activity on AtACT gene expression. Importantly, MEDIATOR25 (MED25) and ORA59 homodimer are also required for ORA59...Continue Reading

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Citations

Oct 24, 2018·Proceedings of the National Academy of Sciences of the United States of America·Qiang GuoGregg A Howe
May 30, 2019·International Journal of Molecular Sciences·Jingjun RuanKaixuan Zhang
Jan 23, 2020·International Journal of Molecular Sciences·Md Sarafat Ali, Kwang-Hyun Baek
Dec 15, 2020·Journal of Experimental Botany·Marwa RoumaniRomain Larbat
Dec 6, 2020·Trends in Plant Science·Jian YeRongxiang Fang
Nov 21, 2020·Current Genomics·Indrani BaruahGeetanjali Baruah
Apr 4, 2021·International Journal of Molecular Sciences·Hai Liu, Michael P Timko
Nov 23, 2021·The Plant Journal : for Cell and Molecular Biology·Valentin MarquisThierry Heitz

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