Jaw osteosarcoma models in mice: first description

Journal of Translational Medicine
Hélios BertinFrançoise Rédini

Abstract

Osteosarcoma (OS) is the most common cancer of bone. Jaw osteosarcoma (JOS) is rare and it differs from other OS in terms of the time of occurrence (two decades later) and better survival. The aim of our work was to develop and characterize specific mouse models of JOS. Syngenic and xenogenic models of JOS were developed in mice using mouse (MOS-J) and human (HOS1544) osteosarcoma cell lines, respectively. An orthotopic patient-derived xenograft model (PDX) was also developed from a mandibular biopsy. These models were characterized at the histological and micro-CT imaging levels, as well as in terms of tumor growth and metastatic spread. Homogeneous tumor growth was observed in both the HOS1544 and the MOS-J JOS models by injection of 0.25 × 106 and 0.50 × 106 tumor cells, respectively, at perimandibular sites. Histological characterization of the tumors revealed features consistent with high grade conventional osteosarcoma, and the micro-CT analysis revealed both osteogenic and osteolytic lesions. Early metastasis was encountered at day 14 in the xenogenic model, while there were no metastatic lesions in the syngenic model and in the PDX models. We describe the first animal model of JOS and its potential use for therapeutic a...Continue Reading

References

Jan 1, 1996·Journal of Cancer Research and Clinical Oncology·C W MillerH P Koeffler
Jul 14, 2006·Critical Reviews in Oncology/hematology·Eugene T H EkPeter F M Choong
Oct 13, 2006·Journal of Cancer Research and Clinical Oncology·Crispin R DassPeter F M Choong
Oct 27, 2006·Pediatric Blood & Cancer·Peter J HoughtonMalcolm A Smith
Jan 24, 2007·Oral Diseases·E H NissankaW M Tilakaratne
Jun 17, 2008·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Wei-liang ChenHai-gang Li
Mar 10, 2010·Cancer Treatment and Research·Giulia Ottaviani, Norman Jaffe
Apr 3, 2010·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Brigitte LacourJacqueline Clavel
Aug 11, 2010·Bone·Katherine A Janeway, Carl R Walkley
Feb 4, 2011·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·Megan Granowski-LeCornuMeredith August
Aug 27, 2011·Critical Reviews in Oncology/hematology·Juliette ThariatNicolas Isambert
Dec 19, 2013·Cancer Treatment Reviews·Anja LuetkeHeribert Juergens
Apr 8, 2014·Cancer·Justin StebbingDavid Sidransky
Aug 8, 2014·Frontiers in Oncology·Maria V GuijarroC Parker Gibbs
Mar 27, 2015·JAMA Otolaryngology-- Head & Neck Surgery·Robert J LeeRussell E Christensen
May 1, 2015·Journal of Translational Medicine·Claudia BlattmannAndreas E Kulozik
May 4, 2015·Cellular and Molecular Life Sciences : CMLS·Arantzazu AlfrancaRene Rodriguez
May 20, 2015·BoneKEy Reports·Özge UluçkanAnthony J Mutsaers
Mar 25, 2016·Pathobiology : Journal of Immunopathology, Molecular and Cellular Biology·Guilhem Bousquet, Anne Janin
Jun 3, 2016·The Journal of Bone and Joint Surgery. American Volume·Ferdinand WagnerDietmar W Hutmacher
May 14, 2017·Journal of Hematology & Oncology·Yunxin LaiPeng Li
Dec 14, 2017·Journal of Cellular Biochemistry·Mannu K WaliaCarl R Walkley
Apr 25, 2018·Journal of Translational Medicine·Wan LuLi Zhihong

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Methods Mentioned

BETA
surgical resection
scraping
biopsy
X-ray
Xenograft

Software Mentioned

GraphPad
CTVox
GraphPad Prism
NRecon
ARRIVE
CTAn
NDPView2

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