JAZF1 ameliorates age and diet-associated hepatic steatosis through SREBP-1c -dependent mechanism

Cell Death & Disease
Qin WeiLing Li

Abstract

JAZF zinc finger 1 (JAZF1) is involved in glucose and lipid metabolisms. However, its role in aging- and nutrient-related hepatic steatosis is unclear. In the current study, we demonstrated that JAZF1 expression was markedly down-regulated in obesity-associated mice and nonalcoholic fatty liver disease (NAFLD) patients. During aging, JAZF1 expression was gradually down-regulated in both C57BL/6 J and JAZF1-Tg mice. In JAZF1-Tg mice, body fat content and hepatosteatosis were protected from HFD-induced steatosis, and accompanied by decreased lipogenesis gene expression. The inhibitory effects of hepatic steatosis in JAZF1-Tg mice, however, were disappeared during aging. In hepatocytes, over-expression of JAZF1 attenuated, while knockdown of JAZF1 enhanced the expression of lipogenesis genes. The over-expressing of JAZF1 in hepatocytes displayed the increased adenosine monophosphate-activated protein kinase (AMPK) phosphorylation and decreased sterol regulatory element-binding protein 1c (SREBP-1c) expression. The roles of JAZF1 were partially attenuated by Compound C. Mechanistically, JAZF1 suppressed SREBP-1c expression through the inhibition of transcriptional activity of liver X receptor response elements (LXREs) in the SREBP-...Continue Reading

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Citations

Apr 11, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Mengjiao ZhouLing Li
Mar 7, 2019·Diabetes/metabolism Research and Reviews·Zhe-Zhen LiaoXin-Hua Xiao
Aug 20, 2021·Cell & Bioscience·Jain JeongZae Young Ryoo

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