JAZF1 Inhibits Adipose Tissue Macrophages and Adipose Tissue Inflammation in Diet-Induced Diabetic Mice

BioMed Research International
Fanping MengLing Li

Abstract

Juxtaposed with another zinc finger gene 1 (JAZF1) affects gluconeogenesis, insulin sensitivity, lipid metabolism, and inflammation, but its exact role in chronic inflammation remains unclear. This study aimed to examine JAZF1 overexpression in vivo on adipose tissue macrophages (ATMs). Mouse models of high-fat diet- (HFD-) induced insulin resistance were induced using C57BL/6J and JAZF1-overexpressing (JAZF1-OX) mice. The mice were randomized (8-10/group) to C57BL/6J mice fed regular diet (RD) (NC group), C57BL/6J mice fed HFD (HF group), JAZF1-OX mice fed RD (NJ group), and JAZF1-OX mice fed HFD (HJ group). Adipose tissue was harvested 12 weeks later. ATMs were evaluated by flow cytometry. Inflammatory markers were evaluated by ELISA. JAZF1-OX mice had lower blood lipids, blood glucose, body weight, fat weight, and inflammatory markers compared with HF mice (all P < 0.05). JAZF1 overexpression decreased ATM number and secretion of proinflammatory cytokines. JAZF1 overexpression decreased total CD4+ T cells, active T cells, and memory T cells and increased Treg cells. JAZF1 overexpression downregulated IFN-γ and IL-17 levels and upregulated IL-4 levels. JAZF1 overexpression decreased MHCII, CD40, and CD86 in total ATM, CD11c+ ...Continue Reading

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Citations

Aug 22, 2020·Circulation. Genomic and Precision Medicine·Lu-Chen WengSteven A Lubitz
Mar 7, 2019·Diabetes/metabolism Research and Reviews·Zhe-Zhen LiaoXin-Hua Xiao
Jan 16, 2021·International Journal of Molecular Sciences·Tara ProcidaSandra B Hake
Jul 27, 2021·Molecular Metabolism·Zuoyou DingGuohao Wu
Sep 8, 2021·Frontiers in Immunology·Ramon M RodriguezBeatriz Suarez-Álvarez

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Methods Mentioned

BETA
flow cytometry

Software Mentioned

FCAP Array
SPSS

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