JC Virus infected choroid plexus epithelial cells produce extracellular vesicles that infect glial cells independently of the virus attachment receptor.

PLoS Pathogens
Bethany A O'HaraWalter J Atwood

Abstract

The human polyomavirus, JCPyV, is the causative agent of progressive multifocal leukoencephalopathy (PML) in immunosuppressed and immunomodulated patients. Initial infection with JCPyV is common and the virus establishes a long-term persistent infection in the urogenital system of 50-70% of the human population worldwide. A major gap in the field is that we do not know how the virus traffics from the periphery to the brain to cause disease. Our recent discovery that human choroid plexus epithelial cells are fully susceptible to virus infection together with reports of JCPyV infection of choroid plexus in vivo has led us to hypothesize that the choroid plexus plays a fundamental role in this process. The choroid plexus is known to relay information between the blood and the brain by the release of extracellular vesicles. This is particularly important because human macroglia (oligodendrocytes and astrocytes), the major targets of virus infection in the central nervous system (CNS), do not express the known attachment receptors for the virus and do not bind virus in human tissue sections. In this report we show that JCPyV infected choroid plexus epithelial cells produce extracellular vesicles that contain JCPyV and readily transm...Continue Reading

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Jun 12, 2020·Viruses·Raquel Bello-MoralesJosé Antonio López-Guerrero
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Jul 17, 2021·Annual Review of Cell and Developmental Biology·Adeline KervielNihal Altan-Bonnet

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Datasets Mentioned

BETA
GM130

Methods Mentioned

BETA
transmission electron microscopy
flow cytometry
size exclusion chromatography
Protein Assay
PCR
Assay

Key Resources (RRID) Mentioned

CVCL_1926

Software Mentioned

FlowJo
Elements High Content
Nikon High Content Analysis
Elements High Content imaging
GeneMapper ID - X

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