Abstract
The transcriptional regulator JDP2 (Jun dimerization protein 2) has been identified as a prognostic marker for patients to develop heart failure after myocardial infarction. We now performed in vivo studies on JDP2-overexpressing mice, to clarify the impact of JDP2 on heart failure progression. Therefore, during birth up to the age of 4 weeks cardiac-specific JDP2 overexpression was prevented by doxycycline feeding in transgenic mice. Then, JDP2 overexpression was started. Already after 1 week, cardiac function, determined by echocardiography, decreased which was also resembled on the cardiomyocyte level. After 5 weeks blood pressure declined, ejection fraction and cardiac output was reduced and left ventricular dilatation developed. Heart weight/body weight, and mRNA expression of ANP, inflammatory marker genes, collagen and fibronectin increased. Collagen 1 protein expression increased, and fibrosis developed. As an additional sign of elevated extracellular matrix remodeling, matrix metalloproteinase 2 activity increased in JDP2 mice. Thus, JDP2 overexpression is deleterious to heart function in vivo. It can be concluded that JDP2 overexpression provokes cardiac dysfunction in adult mice that is accompanied by hypertrophy and...Continue Reading
References
Jun 1, 1997·Molecular and Cellular Biology·A AronheimM Karin
Mar 7, 2001·FEBS Letters·C JinK K Yokoyama
May 9, 2001·Nucleic Acids Research·M W Pfaffl
Oct 17, 2001·FEBS Letters·S KatzA Aronheim
Sep 13, 2002·The Biochemical Journal·Sigal Katz, Ami Aronheim
Oct 31, 2003·Pflügers Archiv : European journal of physiology·Markus LangerKlaus-Dieter Schlüter
Jun 26, 2004·Circulation Research·Min NianPeter Liu
Mar 7, 2006·Nature Structural & Molecular Biology·Chunyuan JinKazunari K Yokoyama
Apr 25, 2006·Cardiovascular Research·Izhak KehatAmi Aronheim
Jun 16, 2009·Journal of Molecular and Cellular Cardiology·Kirk R HutchinsonPamela A Lucchesi
Sep 19, 2009·Methods in Molecular Biology·Jing Liu, Dean F Rigel
Feb 24, 2010·Journal of Pharmacological and Toxicological Methods·K KupaiP Ferdinandy
Nov 10, 2010·Nature Reviews. Cardiology·Anh L BuiGregg C Fonarow
Jan 5, 2011·Journal of Biomedicine & Biotechnology·Yu-Chang HuangKazunari K Yokoyama
Sep 18, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Gabriella F KocsisTamás Csont
Sep 20, 2012·Biochimica Et Biophysica Acta·Ilona Darlyuk-SaadonAmi Aronheim
Dec 4, 2012·Immunity·Kenta MaruyamaShizuo Akira
Apr 25, 2013·Cardiovascular Research·Christian HillGerhild Euler
Jul 23, 2013·PloS One·Lilach KorenAmi Aronheim
May 20, 2015·Genome Medicine·Agata MaciejakBeata Burzynska
Jul 24, 2015·International Journal of Cardiology·L KorenA Aronheim
Sep 13, 2017·International Journal of Cardiology·R KalfonA Aronheim
Citations
Mar 1, 2019·PloS One·Roy KalfonAmi Aronheim
Apr 26, 2019·International Heart Journal·Cui-Ling JiJin-Guo Zhang
Oct 2, 2020·Molecular Medicine Reports·Shiai Wang, Na Cao
Dec 4, 2020·International Journal of Molecular Sciences·Mariana S ParahulevaGerhild Euler
Mar 26, 2020·Chemosphere·Wenlong HuangKusheng Wu
Jan 22, 2021·Free Radical Biology & Medicine·Jacqueline HegerRainer Schulz
Feb 17, 2021·The Journal of Obstetrics and Gynaecology Research·Xinghua DiaoHe Ma
May 1, 2021·International Journal of Molecular Sciences·Gerhild EulerMariana S Parahuleva
Jul 16, 2021·Frontiers in Cardiovascular Medicine·Chen YifanPu Jun