PMID: 1881137Sep 1, 1991Paper

Jejunal and ileal absorptive function after a model of canine jejunoileal autotransplantation

The Journal of Surgical Research
M G SarrA M Walters

Abstract

The effects of intestinal transplantation on the physiologic functions of the gut are not well understood. Our aim was to determine the effect of a large animal model of small intestinal transplantation (disruption of all neural and lymphatic continuity) on selected absorptive functions of the jejunoileum. Seven dogs were studied before and at 1, 4, and 12 weeks after a model of jejunoileal autotransplantation, which avoids confounding factors of immune rejection, immunosuppression, and harvest ischemia. Jejunal function was assessed by quantitative [3H]-folate and D-xylose absorption and ileal function by quantitative 57Co-vitamin B12 absorption. The role of lymphatic continuity was assessed by fecal fat recovery following 5 days of a controlled, high fat diet (75 g/day). All dogs developed a profuse, watery diarrhea that persisted for 6 to 12 weeks and lost about 15% body weight; however, absorption of D-xylose, folate, and vitamin B12 was unaffected at any time point. Fat absorption postoperatively was only mildly abnormal (less than or equal to 8 g/day) at all time points in five of seven dogs despite complete lymphatic disruption. We concluded that jejunoileal autotransplantation does not markedly affect these specific jej...Continue Reading

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Citations

Aug 1, 1994·Digestive Diseases and Sciences·K E Behrns, M G Sarr
Jul 20, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Michael S KasparekMichael G Sarr
May 30, 2002·Transplantation Proceedings·R-J SchulzA R Mueller
Feb 1, 2003·Annals of Surgery·Toshiyuki TanakaMichael G Sarr
Feb 20, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M S KasparekM G Sarr
Nov 1, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·M S KasparekM G Sarr
Oct 2, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Rebecca A Weseman
Aug 16, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Kotaro IwanamiNoriko Murase
May 1, 1996·Digestive Diseases and Sciences·K E BehrnsA R Zinsmeister
Jun 5, 1998·The American Journal of Physiology·K E BehrnsA R Zinsmeister
May 8, 2021·Scandinavian Journal of Gastroenterology·Yngve ThorsenDejan Ignjatovic

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