Jejunal brake: inhibition of intestinal transit by fat in the proximal small intestine

Digestive Diseases and Sciences
H C LinL Wang

Abstract

Optimal absorption of fat requires adequate time of contact with the absorptive sites of the small intestine. In order to prevent steatorrhea, intestinal transit must be slowed in response to the fat that has emptied into the small intestine. Intestinal transit is known to be inhibited by fat in the ileum via the ileal brake. This response has suggested that the regulation of intestinal transit is a function of the distal small intestine. However, clinical observations suggest that the ileal brake is not the only control mechanism for intestinal transit. In short bowel patients with resection of the ileum, the proportion of fecal fat recovery remained constant even after the fat intake was increased threefold. In these patients, optimal fat absorption based on the slowing of intestinal transit must have been triggered by an inhibitory mechanism located outside of the distal small intestine. To test the hypothesis that fat in the proximal small intestine inhibited intestinal transit, we compared intestinal transit during perfusion of the proximal half of the small intestine with 0 (buffer only), 15, 30, or 60 mM oleate in dogs equipped with duodenal and mid-intestinal fistula. Intestinal transit across a 150-cm test segment (bet...Continue Reading

Citations

Nov 30, 2000·Current Treatment Options in Gastroenterology·E E Soffer
Sep 26, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·L K SummersK N Frayn
Oct 24, 2001·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A A BurnsI R Rowland
Jun 6, 2003·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·H C Lin, J H Chen
Nov 14, 2003·American Journal of Physiology. Gastrointestinal and Liver Physiology·Henry C LinJin Hai Chen
Feb 5, 2015·Journal of Comparative Physiology. B, Biochemical, Systemic, and Environmental Physiology·R G Lentle, C de Loubens
Apr 17, 2015·Nutrition Journal·Magdy El-Salhy, Doris Gundersen
Jan 23, 1998·JPEN. Journal of Parenteral and Enteral Nutrition·S KleinJ L Rombeau
Sep 14, 2006·Current Gastroenterology Reports·Gregg W Van Citters, Henry C Lin
Jan 27, 2006·European Journal of Clinical Investigation·M G PriebeR J Vonk
Nov 19, 2005·American Journal of Physiology. Gastrointestinal and Liver Physiology·Mark PimentelJeffrey Conklin
Jan 15, 2009·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·N L ClunyK A Sharkey
Dec 1, 1996·Digestive Diseases and Sciences·N VidonS Chaussade
Jan 11, 2000·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A A BurnsI R Rowland
Aug 29, 2002·Alimentary Pharmacology & Therapeutics·A Szilagyi
Jul 1, 2005·Digestive Diseases and Sciences·Henry C LinUNKNOWN AMS Task Force Committee on Gastrointestinal Transit
Jun 22, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·X T ZhaoH C Lin
Jan 30, 1999·The American Journal of Clinical Nutrition·I M ChapmanM Horowitz
Sep 22, 2000·Current Gastroenterology Reports·E E Soffer
Mar 29, 2002·Clinical and Experimental Pharmacology & Physiology·Tuğba TopçuCumhur Yeğen
Sep 12, 2000·Current Gastroenterology Reports·G W Van Citters, H C Lin
Dec 25, 2012·JPEN. Journal of Parenteral and Enteral Nutrition·Laura E Matarese
Apr 19, 2017·Clinical and Experimental Pharmacology & Physiology·Anthony Y LinGregory O'Grady
Apr 17, 2008·Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine·Giuliano MarianiH William Strauss
Aug 8, 2006·Gastroenterology·Michael Camilleri

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