PMID: 2510065Jan 1, 1989Paper

Jejunal dialysis in man using mannitol as the perfusate

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
C G Newstead

Abstract

In four normal subjects a 50-cm segment of the jejunum was perfused through a multilumen tube with either hypertonic (1300 mOsm/kg) or isotonic mixtures of mannitol and water at rates between 18 and 70 ml/min. There was no difference in the solute clearances produced by the two solutions. Mean clearances (ml/min) were urea 23, creatinine 8, urate 4. Ninety-five mmol of sodium and 3.8 mmol of potassium were removed during a 1-h perfusion period. Clearances of glucose, calcium, phosphate and protein were negligible. Mean free water clearance was 0.5 ml/min during isotonic perfusion and 22.4 ml/min during hypertonic perfusion. These clearances of urea and creatinine are similar to those previously reported during perfusion of the whole bowel in uraemic patients with isotonic mannitol and during segmental jejunal perfusion with glucose/sodium mixtures. Over the range of flow rates studied there was a positive linear relationship between perfusate flow rates might achieve clinically useful solute clearance. However, the efficacy of the method in prolonged perfusion of uraemic patients may be different from that seen in normal subjects.

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.