Jiangtang decoction ameliorate diabetic nephropathy through the regulation of PI3K/Akt-mediated NF-κB pathways in KK-Ay mice

Chinese Medicine
Jin-Ni HongXue-Mei Wang

Abstract

Jiangtang decoction (JTD) is a China patented drug which contains Euphorbia humifusa Willd, Salvia miltiorrhiza Bunge, Astragalus mongholicus Bunge, Anemarrhena asphodeloides Bunge, and Coptis chinensis Franch. For decades, it has also been used clinically to treat diabetic nephropathy (DN) effectively; however, the associated mechanisms remain unknown. Thus, the present study aimed to examine the protective efficacy of JTD in DN and elucidate the underlying molecular mechanisms. A diabetic model using KK-Ay mice received a daily administration of JTD for 12 weeks. Body weight, blood glucose, triglycerides (TGs), total cholesterol (TC), urea nitrogen (UN), creatinine (Cr), and microalbumin/urine creatinine (MA/UCREA) was measured every 4 weeks. Furthermore, on the day of the sacrifice, blood, urine, and kidneys were collected to assess renal function according to general parameters. Pathological staining was performed to evaluate the protective renal effect of JTD. In addition, the levels of inflammatory cytokines (tumor necrosis factor-α [TNF-α], interleukin [IL]-6 and intercellular adhesion molecule [ICAM]-1), insulin receptor substrate [IRS]-1, advanced glycation end products [AGEs], and receptor of glycation end products [R...Continue Reading

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Citations

Jul 31, 2020·Archives of Physiology and Biochemistry·Kirti Parwani, Palash Mandal
Aug 14, 2018·Archives of Pharmacal Research·Jinni HongWeiwei Li
Aug 28, 2020·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nutthapoom Pathomthongtaweechai, Somchai Chutipongtanate
May 25, 2021·Frontiers in Physiology·Bao-Yi ShaoHai-Yong Chen
Jun 3, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Aswir Abd Rashed, Devi-Nair Gunasegavan Rathi
Jun 29, 2021·Journal of Diabetes and Metabolic Disorders·Olusola Olalekan ElekofehintiOluwamodupe Cecilia Ejelonu

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Methods Mentioned

BETA
ELISA
electrophoresis
PCR
electron microscopy
biopsies

Software Mentioned

Image
Pro Plus

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