Jiedu Tongluo Granules Ameliorates Post-stroke Depression Rat Model via Regulating NMDAR/BDNF Signaling Pathway.

Frontiers in Pharmacology
Ai-Mei ZhaoJian-Xun Liu

Abstract

Post-stroke depression (PSD) is one of the most common stroke complications, which seriously affects stroke's therapeutic effect and brings great pain for patients. The pathological mechanism of PSD has not been revealed. Jiedu Tongluo granules (JDTLG) is an effective traditional Chinese medicine for PSD treatment which is widely used in clinical treatment. JDTLG has a significant therapeutic effect against PSD, but the mechanism is still unclear. The PSD rat model was established by carotid artery embolization combined with chronic sleep deprivation followed by treating with JDTLG. Neurobehavioral and neurofunctional experiments were engaged in studying the neural function of rats. Histomorphology, proteomics, and western blotting researches were performed to investigate the potential molecular mechanisms related to JDTLG therapy. Oral treatment of JDTLG could significantly improve the symptoms of neurological deficit and depression symptoms of PSD rats. Proteomic analysis identified several processes that may involve the regulation of JDTLG on the PSD animal model, including energy metabolism, nervous system, and N-methyl-D-aspartate receptor (NMDAR)/brain-derived neurotrophic factor (BDNF) signal pathway. Our results showed ...Continue Reading

References

Jan 1, 1989·Stroke; a Journal of Cerebral Circulation·E Z LongaR Cummins
Jun 1, 1996·Stroke; a Journal of Cerebral Circulation·J CastilloM Noya
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Jun 28, 2003·CNS Drugs·D Allan Butterfield, Chava B Pocernich
Apr 25, 2006·Biological Psychiatry·Ronald S Duman, Lisa M Monteggia
Apr 22, 2008·Nature Reviews. Drug Discovery·Gerard SanacoraHusseini K Manji
Feb 20, 2010·Cell Calcium·Kinga Szydlowska, Michael Tymianski
May 17, 2011·Pharmacology, Biochemistry, and Behavior·Carlos Riaza Bermudo-SorianoEnrique Baca-Garcia
Oct 12, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Emily G WaterhouseBaoji Xu
Mar 23, 2015·Current Neurology and Neuroscience Reports·Réjean M GuerrieroAlexander Rotenberg
Jul 15, 2015·Drug Design, Development and Therapy·Felix FluriChristoph Kleinschnitz
Nov 1, 2015·Neuropharmacology·Carl Björkholm, Lisa M Monteggia
Jan 14, 2016·Annals of Medicine·Karen SchmittAnne Eckert
Sep 30, 2016·Acta Neurobiologiae Experimentalis·Filiz Civil ArslanÖznur Gedikli
Dec 10, 2016·Stroke; a Journal of Cerebral Circulation·Amytis TowfighiUNKNOWN American Heart Association Stroke Council; Council on Cardiovascular and Stroke Nursing; and Council on Quality of Care and
Jan 9, 2017·Acta Neuropathologica·Clemens J Sommer
Sep 1, 2017·Restorative Neurology and Neuroscience·Yefei SunChuansheng Zhao
Nov 13, 2017·Pharmacology & Therapeutics·Roberto Federico VillaAntonio Moretti
Apr 27, 2018·Frontiers in Pharmacology·Sara R TanqueiroMaria J Diógenes
Nov 6, 2018·Nucleic Acids Research·Yasset Perez-RiverolJuan Antonio Vizcaíno
Feb 8, 2019·Frontiers in Psychiatry·Zan WangFang Deng

❮ Previous
Next ❯

Software Mentioned

GraphPad Prism

Related Concepts

Related Feeds

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.