Jin Gui Shen Qi Wan, a traditional Chinese medicine, alleviated allergic airway hypersensitivity and inflammatory cell infiltration in a chronic asthma mouse model

Journal of Ethnopharmacology
Shung-Te KaoLi-Jen Lin

Abstract

In Asia, Jin Gui Shen Qi Wan (JGSQW) has been used for hundreds of years to treat asthma. The traditional Chinese medicine JGSQW is composed of Rehmannia glutinosa, Dioscorea opposita, Cornus officinalis, Poria cocos, Paeonia suffruticosa, Alisma orientalis, Aconitum carmichaelii and Cinnamomum cassia. However, the immunological mechanism underlying the effect of JGSQW treatment on asthma remains unclear. This study examined whether JGSQW has the potential to reduce asthma symptoms in mice with chronic asthma induced by recurrent Dermatophagoides pteronyssinus (Der p) stimulation, as well as its immunoregulatory mechanisms. The airways of BALB/c mice were stimulated with Der p (i.t.) once per week (50 μL, 1 mg/mL) for 6 consecutive weeks, and the mice were fed JGSQW (1 g/kg) 30 min prior to the Der p stimulation. Three days after the last stimulation, the mice were sacrificed to evaluate the airway remodelling, infiltration of inflammatory cells, lung histological features, and total IgE in the blood. Additionally, after A549 cells were treated with JGSQW, loganin, or paeoniflorin for 30 min, 10 ng/mL IL-1β was added to stimulate the A549 cells to evaluate the effect of the medicine on the ICAM-1 gene expression after IL-1β sti...Continue Reading

Citations

Sep 24, 2020·Evidence-based Complementary and Alternative Medicine : ECAM·Qi ShangHui Ren
Nov 14, 2020·Journal of Ethnopharmacology·Jun-Xi LiuJun Liang
Mar 13, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Chung-Jen ChiangLi-Jen Lin

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