jing is required for wing development and to establish the proximo-distal axis of the leg in Drosophila melanogaster

Genetics
Joaquim CuliRichard S Mann

Abstract

The establishment of the proximo-distal (PD) axis in the legs of Drosophila melanogaster requires the expression of a nested set of transcription factors that are activated in discreet domains by secreted signaling molecules. The precise regulation of these transcription factor domains is critical for generating the stereotyped morphological characteristics that exist along the PD axis, such as the positioning of specific bristle types and leg joints. Here we provide evidence that the Zn-finger protein encoded by the gene jing is critical for PD axis formation in the Drosophila legs. Our data suggest that jing represses transcription and that it is necessary to keep the proximal gene homothorax (hth) repressed in the medial domain of the PD axis. We further show that jing is also required for alula and vein development in the adult wing. In the wing, Jing is required to repress another proximal gene, teashirt (tsh), in a small domain that will give rise to the alula. Interestingly, we also demonstrate that two other genes affecting alula development, Alula and elbow, also exhibit tsh derepression in the same region of the wing disc as jing- clones. Finally, we show that jing genetically interacts with several members of the Pol...Continue Reading

References

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Citations

Nov 10, 2010·Development Genes and Evolution·Tatiana MorozovaMargaret Sonnenfeld
Nov 10, 2010·Development Genes and Evolution·Margaret SonnenfeldXuetao Sun
Apr 21, 2012·Proceedings of the National Academy of Sciences of the United States of America·Leslie Y BehNicole J Francis
Mar 19, 2009·Nucleic Acids Research·Hana KimJoomyeong Kim
May 12, 2007·Trends in Cell Biology·Hai WuGerald R Crabtree
Nov 26, 2013·Developmental Biology·William A RogersThomas M Williams
Nov 27, 2007·Mechanisms of Development·Kimberly D McClure, Gerold Schubiger
Jan 3, 2009·Mechanisms of Development·David ForondaFrancisco A Martín
Aug 6, 2017·Genetics·Judith A KassisJohn W Tamkun

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