JMJ24 targets CHROMOMETHYLASE3 for proteasomal degradation in Arabidopsis

Genes & Development
Shulin DengNam-Hai Chua

Abstract

H3K9 methylation is usually associated with DNA methylation, and together they symbolize transcriptionally silenced heterochromatin. A number of proteins involved in epigenetic processes have been characterized. However, how the stability of these proteins is regulated at the post-translational level is largely unknown. Here, we show that an Arabidopsis JmjC domain protein, JMJ24, possesses ubiquitin E3 ligase activity. JMJ24 directly targets a DNA methyltransferase, CHROMOMETHYLASE 3 (CMT3), for proteasomal degradation to initiate destabilization of the heterochromatic state of endogenous silenced loci. Our results uncover an additional connection between two conserved epigenetic modifications: histone modification and DNA methylation.

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Citations

Sep 16, 2018·The Plant Journal : for Cell and Molecular Biology·Di FanKeming Luo
Jan 1, 2019·Bioinformatics·Tamir TullerDaniel A Chamovitz
May 28, 2019·The New Phytologist·Tao YaoNam-Hai Chua
Oct 15, 2019·Frontiers in Plant Science·Sandra Fonseca, Vicente Rubio

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