PMID: 15377263Sep 21, 2004Paper

JNK: a key modulator of intracellular signaling

Biochemistry. Biokhimii︠a︡
S Vlahopoulos, V C Zoumpourlis

Abstract

JNK is a family of stress activated protein kinase enzymes that is under intense study. JNK family members are involved in diverse phenomena, but the focus of research has been until now involvement of JNK in apoptosis. A great number of JNK substrates indeed play major roles in cell death. Conversely, accumulating data supports a key role of JNK substrates in cell survival and proliferation. Continuous progress is being made, while several important questions remain unanswered. Does JNK cause cancer or prevent it? This paper attempts to evaluate the role of JNK in cell physiology and describe the effects of intracellular signaling pathways that are mediated by JNK family members.

Citations

May 25, 2007·Nature Reviews. Molecular Cell Biology·Armando van der Horst, Boudewijn M T Burgering
Apr 22, 2009·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·John A CoplandSpiros A Vlahopoulos
Feb 5, 2015·BioMed Research International·Sreekanth PuttacharyThimmasettappa Thippeswamy
Dec 3, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Juan P ParodyMaria C Carrillo
Jul 28, 2011·Journal of Cellular Physiology·Marina Di DomenicoEttore Cassandro
Aug 13, 2013·Human Molecular Genetics·Pearl P C TohDavid C Rubinsztein
Jul 22, 2018·Frontiers in Pharmacology·Maria ShvedovaDmitriy N Atochin
Jul 23, 2014·Mediators of Inflammation·Tao YuJae Youl Cho
Sep 12, 2012·International Journal of Cancer. Journal International Du Cancer·Benedikt GröschlWolfgang Dietmaier
Nov 3, 2015·Expert Review of Anticancer Therapy·Maria MoschoviSpiros Vlahopoulos
Dec 7, 2018·International Journal of Molecular Sciences·Michał CiebieraGrzegorz Jakiel
Mar 19, 2008·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Spiros A VlahopoulosVassilis Zoumpourlis
Sep 16, 2011·The Laryngoscope·Peter L Santa MariaReza Ghassemifar
Oct 30, 2020·Cells·Nina D AnfinogenovaDmitriy N Atochin
Apr 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Lili ZhangGuangqun Xing

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Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis