JNK in spinal cord facilitates bone cancer pain in rats through modulation of CXCL1

Journal of Huazhong University of Science and Technology. Medical Sciences = Hua Zhong Ke Ji Da Xue Xue Bao. Yi Xue Ying De Wen Ban = Huazhong Keji Daxue Xuebao. Yixue Yingdewen Ban
Zhong-Liang WangRui-Guang Zhang

Abstract

In patients with advanced cancer, cancer-induced bone pain (CIBP) is a severe and common problem that is difficult to manage and explain. As c-Jun N-terminal kinase (JNK) and chemokine (C-X-C motif) ligand 1 (CXCL1) have been shown to participate in several chronic pain processes, we investigated the role of JNK and CXCL1 in CIBP and the relationship between them. A rat bone cancer pain model was established by intramedullary injection of Walker 256 rat gland mammary carcinoma cells into the left tibia of Sprague-Dawley rats. As a result, intramedullary injection of Walker 256 carcinoma cells induced significant bone destruction and persistent pain. Both phosphorylated JNK1 (pJNK1) and pJNK2 showed time-dependent increases in the ipsilateral spinal cord from day 7 to day 18 after tumor injection. Inhibition of JNK activation by intrathecal administration of SP600125, a selective pJNK inhibitor, attenuated mechanical allodynia and heat hyperalgesia caused by tumor inoculation. Tumor cell inoculation also induced robust CXCL1 upregulation in the ipsilateral spinal cord on day 18 after tumor injection. Inhibition of CXCL1 by intrathecal administration of CXCL1 neutralizing antibody showed a stable analgesic effect. Intrathecal adm...Continue Reading

References

Aug 11, 1998·Journal of Neuroscience Research·D M McTigueB T Stokes
May 18, 2001·Brain Research. Developmental Brain Research·D Nguyen, M Stangel
Apr 5, 2002·Pain·S J MedhurstL Urban
Sep 11, 2003·Developmental Neuroscience·R FilipovicN Zecevic
Mar 19, 2005·Brain : a Journal of Neurology·Kakuri M OmariCedric S Raine
Jul 28, 2005·Journal of Neuroscience Research·Xiaomei QinXian Wang
May 27, 2006·Biochemical and Biophysical Research Communications·Qi-Liang Mao-YingYan-Qing Wang
Dec 13, 2006·Microbiology and Molecular Biology Reviews : MMBR·Marie A Bogoyevitch, Bostjan Kobe
Nov 9, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ji ZhangSerge Rivest
Dec 18, 2007·Proceedings of the National Academy of Sciences of the United States of America·Fletcher A WhiteRichard J Miller
May 6, 2008·Neuroscience Letters·Yong-Jing Gao, Ru-Rong Ji
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yong-Jing GaoRu-Rong Ji
Apr 16, 2013·Pain·Gillian L CurrieMarie T Fallon

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Citations

Sep 16, 2016·Frontiers in Pharmacology·Priyank A ShenoyMaree T Smith
Aug 21, 2018·Pharmacological Reports : PR·Klaudia Kwiatkowski, Joanna Mika

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