JNK Regulation of Depression and Anxiety

Brain Plasticity
Patrik HollosEleanor T Coffey

Abstract

Depression and anxiety are the most common mood disorders affecting 300 million sufferers worldwide. Maladaptive changes in the neuroendocrine stress response is cited as the most common underlying cause, though how the circuits underlying this response are controlled at the molecular level, remains largely unknown. Approximately 40% of patients do not respond to current treatments, indicating that untapped mechanisms exist. Here we review recent evidence implicating JNK in the control of anxiety and depressive-like behavior with a particular focus on its action in immature granule cells of the hippocampal neurogenic niche and the potential for therapeutic targeting for affective disorders.

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Citations

Feb 23, 2020·Cells·Emilia KomulainenEleanor T Coffey
Dec 15, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Mei YangXun Ai
Aug 19, 2020·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Haiyang ZhangHonggang Fan
Jan 7, 2021·Journal of Drug Targeting·Jian-Hong Qi, Fang-Xu Dong
Nov 18, 2020·Diabetologia·Rubén Nogueiras, Guadalupe Sabio
Aug 26, 2021·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Xiang LiHui-Li Jiang
Jun 30, 2021·Annals of the New York Academy of Sciences·Francisco Stefânio BarretoDanielle S Macedo

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