Job stress, gene polymorphism of beta2-AR, and prevalence of hypertension

Biomedical and Environmental Sciences : BES
Shan-Fa YuSheng Wang

Abstract

To study the interactive effect of job stress and genetic susceptibility (or gene polymorphism) on hypertension. A cross-sectional epidemiological study was conducted in 452 workers from a thermal power plant in China. Extrinsic effort, occupational reward, and over-commitment were measured. Hypertensive patients were defined by three phases of screening, reexamination, and final diagnosis. beta2-AR genotypes and allele frequencies at amino acid positions 16 (beta2-AR-16: Arg-->Gly) and 27 (beta2-AR-27: Gln-->Glu) were identified by PCR-RFLP. Job stress was related with the prevalence of hypertension in males (P < 0.05), whereas no significant relationship was found in females (P > 0.05). Differences in genotypes and allele frequencies of the beta2-AR-16 were statistically significant between the hypertension and control groups (P < 0.05), whereas those of beta2-AR-27 were not (P > 0.05). The prevalence of hypertension was higher in individuals carrying Gly16 allele than in those carrying Arg16 allele of the high job stress group (P < 0.01 or 0.05). High job stress and polymorphism of beta2-AR-16 have an interactive effect on the prevalence of hypertension in male workers.

References

Feb 5, 2004·Social Science & Medicine·Johannes SiegristRichard Peter
Oct 16, 2004·Journal of Epidemiology and Community Health·Johannes Siegrist

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Citations

Aug 27, 2010·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Yuqing LouShaojun Wen
Oct 17, 2009·Industrial Health·Kazuhito Yokoyama
Oct 24, 2009·Revista de saúde pública·Márcia Guimarães de Mello AlvesClaudia S Lopes

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