Joint Aspiration for Acute Hemarthrosis in Children Receiving Factor VIII Prophylaxis for Severe Hemophilia: 11-year Safety Data

The Journal of Rheumatology
Prudence J MannersCatherine H Cole

Abstract

The aims of this study were (1) to document the prevalence of acute hemarthrosis in a cohort of 46 boys with severe hemophilia A receiving full primary prophylaxis in Western Australia (WA), and (2) to investigate the safety of the WA protocol over 11 years for management of hemarthrosis. Case review. The WA protocol involves a pediatric rheumatologist washing out all acute hemarthrosis of large joints promptly and then instilling intraarticular (IA) corticosteroids. This study showed that joint bleeds occurred in 22 boys of 46 (47.8%). In over 11 years, 84 washouts were performed on 32 joints in 22 boys. No adverse events occurred. Fifteen of 22 boys had normal joints with a Hemophilic Joint Health Score = 0. Fifteen boys who had had all hemarthrosis washed out had clinically normal joints (100%). Seven boys had sustained joint damage prior to full instigation of the protocol, each having had documented hemarthrosis without aspiration. Parents needed to understand that joint bleeds constituted an emergency. Of our cohort, 47.8% of patients with severe hemophilia receiving prophylaxis developed joint bleeding. The WA protocol is safe. There is evidence suggesting joint outcomes of hemophilic patients having hemarthrosis despite...Continue Reading

References

Apr 24, 2003·Haemophilia : the Official Journal of the World Federation of Hemophilia·M J Manco-Johnson, V S Blanchette
Aug 3, 2004·Pediatrics·Chris BarnesPaul Monagle
Jan 22, 2005·Haemophilia : the Official Journal of the World Federation of Hemophilia·S A BrownUNKNOWN Round Table Group
Jan 24, 2006·Seminars in Hematology·Pradeep M Poonnoose, Alok Srivastava
May 11, 2006·Haemophilia : the Official Journal of the World Federation of Hemophilia·G Roosendaal, F P Lafeber
Aug 10, 2007·The New England Journal of Medicine·Marilyn J Manco-JohnsonBruce L Evatt
Oct 18, 2007·Haemophilia : the Official Journal of the World Federation of Hemophilia·W K HootsL A Valentino
Oct 2, 2007·Patient Education and Counseling·Julie H BarlowDavid R Ellard
Oct 28, 2008·British Journal of Haematology·Nathalie W D JansenFloris P J G Lafeber
Aug 23, 2012·Haemophilia : the Official Journal of the World Federation of Hemophilia·A L ForsythF Forriol
Oct 15, 2013·Thrombosis Research·E Carlos Rodriguez-MerchanVictor Jimenez-Yuste

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Citations

Dec 5, 2015·Haemophilia : the Official Journal of the World Federation of Hemophilia·M A TimmerR E G Schutgens
May 12, 2016·Blood Reviews·E Carlos Rodriguez-Merchan
Apr 9, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Hortensia De la Corte-RodriguezVictor Jimenez-Yuste
Aug 24, 2017·JBJS Reviews·Alexander D Liddle, E Carlos Rodriguez-Merchan
Sep 28, 2018·HSS Journal : the Musculoskeletal Journal of Hospital for Special Surgery·Hortensia De la Corte-RodriguezVíctor Jimenez-Yuste
Sep 14, 2019·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·E Carlos Rodriguez-Merchan
Apr 4, 2017·Haemophilia : the Official Journal of the World Federation of Hemophilia·J HanleyUNKNOWN Musculoskeletal Working Party of the UKHCDO
Jan 21, 2021·Haemophilia : the Official Journal of the World Federation of Hemophilia·Wenbin LiuBaodong Ye
Jun 26, 2021·Nature Reviews. Disease Primers·Erik BerntorpVictor Blanchette
Jul 2, 2021·Journal of Thrombosis and Haemostasis : JTH·Roberta GualtierottiFlora Peyvandi

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