Joint association between body fat and its distribution with all-cause mortality: A data linkage cohort study based on NHANES (1988-2011)

PloS One
Bin DongYing-Hua Ma

Abstract

Although obesity is recognized as an important risk of mortality, how the amount and distribution of body fat affect mortality risk is unclear. Furthermore, whether fat distribution confers any additional risk of mortality in addition to fat amount is not understood. This data linkage cohort study included 16415 participants (8554 females) aged 18 to 89 years from National Health and Nutrition Examination Survey III (1988-1994) and its linked mortality data (31 December 2011). Cox proportional hazard models and parametric survival models were used to estimate the association between body fat percentage (BF%), based on bioelectrical impedance analysis, and waist-hip ratio (WHR) with mortality. A total of 4999 deaths occurred during 19-year follow-up. A U-shaped association between BF% and mortality was found in both sexes, with the adjusted hazard ratios for other groups between 1.02 (95% confidence interval: 0.89, 1.18) and 2.10 (1.47, 3.01) when BF% groups of 25-30% in males and 30-35% in females were used as references. A non-linear relationship between WHR and mortality was detected in males, with the adjusted hazard ratios among other groups ranging from 1.05 (0.94, 1.18) to 1.52 (1.15, 2.00) compared with the WHR category ...Continue Reading

References

Mar 16, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·D B AllisonM Heo
Dec 4, 2002·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·W C ChumleaV S Hubbard
Dec 6, 2003·Hypertension·Aram V ChobanianUNKNOWN National High Blood Pressure Education Program Coordinating Committee
Nov 14, 2008·The New England Journal of Medicine·T PischonE Riboli
Jan 11, 2013·Physiological Reviews·André Tchernof, Jean-Pierre Després
Dec 21, 2013·Diabetes Care·UNKNOWN American Diabetes Association
May 11, 2016·JAMA : the Journal of the American Medical Association·Shoaib AfzalBørge G Nordestgaard

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Citations

Aug 12, 2018·Journal of Lipid Research·Aaron P FrankDeborah J Clegg
Jan 9, 2020·International Journal of Obesity : Journal of the International Association for the Study of Obesity·Orison O Woolcott, Richard N Bergman
Jul 25, 2019·Eating and Weight Disorders : EWD·Rejane Rosaria Grecco Dos SantosRita Mattiello
Jan 8, 2021·BMC Public Health·Yuan-I MinAdolfo Correa

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