Joint associations of β-amyloidosis and cortical thickness with cognition

Neurobiology of Aging
David S KnopmanClifford R Jack

Abstract

In 1164 cognitively unimpaired persons, aged 50-95 years, from the population-based Mayo Clinic Study of Aging, we examined the relationships of baseline cognition and cognitive changes across the full range of cortical thickness of an Alzheimer signature region of interest and global β-amyloid levels measured by Pittsburgh compound B positron emission tomography (PIB PET) standardized uptake value ratio (SUVR). In machine-learning models accounting for both biomarkers simultaneously, worsening biomarker values were additive and associated with lower baseline global cognition and greater subsequent decline in global cognition. Associations between Alzheimer's disease signature cortical thickness or PIB PET β-amyloid SUVR and baseline cognition were mainly linear. Lower Alzheimer's disease signature cortical thickness values across the entire range of thickness predicted future decline in global cognitive scores, demonstrating its close relationship to cognitive functioning. PIB PET β-amyloid SUVR also predicted cognitive decline across its full range, even when cortical thickness was accounted for. PIB PET β-amyloid's relationship to cognitive decline was nonlinear, more prominent at lower β-amyloid levels and less prominent at...Continue Reading

Citations

Feb 14, 2019·Brain : a Journal of Neurology·David S KnopmanClifford R Jack
Sep 12, 2019·Annals of Neurology·Prashanthi VemuriClifford R Jack
Mar 10, 2019·Scientific Reports·Pierrick CoupéGwenaelle Catheline
Jul 19, 2019·Frontiers in Aging Neuroscience·François R HerrmannPanteleimon Giannakopoulos
Sep 15, 2020·Journal of Alzheimer's Disease : JAD·Marie-Louise MontandonPanteleimon Giannakopoulos
Jul 28, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Shady RahayelSven Joubert
Dec 6, 2019·Frontiers in Neuroscience·Sven HallerPanteleimon Giannakopoulos
May 8, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Elizabeth E MooreAngela L Jefferson
Jul 30, 2021·Frontiers in Aging Neuroscience·Panteleimon GiannakopoulosFrançois R Herrmann
Sep 29, 2021·Human Brain Mapping·Binyin LiUNKNOWN Alzheimer's Disease Neuroimaging Initiative

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