Joint associations of folate, homocysteine and MTHFR, MTR and MTRR gene polymorphisms with dyslipidemia in a Chinese hypertensive population: a cross-sectional study

Lipids in Health and Disease
Wen-Xing LiJing-Fei Huang

Abstract

Dyslipidemia is a well-established risk factor for cardiovascular disease. Serum lipids were affected by several gene polymorphisms, folate, homocysteine and other metabolite levels. We aim to investigate the effects of homocysteine metabolism enzyme polymorphisms (MTHTR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G) and their interactions with folate, homocysteine on serum lipid levels in Chinese patients with hypertension. Participants were 480 hypertensive adults that enrolled in September to December 2005 from six different Chinese hospitals (Harbin, Shanghai, Shenyang, Beijing, Xi'an, and Nanjing). Known MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G genotypes were determined by PCR-RFLP methods. Serum folate was measured by chemiluminescent immunoassay, homocysteine was measured by high-performance liquid chromatography, serum lipids parameters were determined by an automatic biochemistry analyzer, low-density lipoprotein was calculated by Friedewald's equation. Unitary linear regression model was used to assess the associations of gene polymorphisms, folate and homocysteine on serum lipid profiles. Unconditional logistic regression model was applied to test the interactions of folate, homocysteine and gene polymorph...Continue Reading

References

May 1, 1982·The British Journal of Nutrition·B AkessonU Stenram
Apr 18, 1998·Proceedings of the National Academy of Sciences of the United States of America·D LeclercR A Gravel
Mar 24, 1998·Annual Review of Medicine·H RefsumS E Vollset
Dec 26, 2001·The British Journal of Nutrition·E NakanoH J Powers
Jan 15, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·M C VerhaarT J Rabelink
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Connie W H WooKarmin O
Aug 1, 2006·Journal of Pediatric Gastroenterology and Nutrition·Marie-Laure FrelutGeneviève Potier de Courcy
Aug 19, 2007·The British Journal of Nutrition·Christopher J McNeilWilliam D Rees
Dec 7, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·J M BiselliE C Pavarino-Bertelli
Jun 24, 2008·Pathophysiology : the Official Journal of the International Society for Pathophysiology·L A Olatunji, A O Soladoye
Jan 15, 2009·Journal of Lipid Research·Baohai Shao, Jay W Heinecke
Mar 28, 2009·FEBS Letters·Rima Obeid, Wolfgang Herrmann
Jul 30, 2010·Nutrition Journal·Alexander SemmlerMichael Linnebank
Sep 3, 2010·Journal of Atherosclerosis and Thrombosis·Dal-Sik KimSeul-Ki Jeong
Aug 8, 2012·Journal of Human Reproductive Sciences·Madhu JainShuchi Jain
Nov 29, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Shanqun JiangYi-Hsiang Hsu
Jul 5, 2013·Canadian Journal of Public Health = Revue Canadienne De Santé Publique·Michel JoffresSarah Connor Gorber
Nov 6, 2013·Current Vascular Pharmacology·Livia PisciottaAldo Pende
Nov 14, 2013·European Journal of Clinical Nutrition·E C RushC S Yajnik
Dec 20, 2013·BioFactors·Robin P da SilvaRené L Jacobs
Jan 25, 2014·European Journal of Nutrition·Lise Lotte N HusemoenAllan Linneberg
Jun 28, 2014·Lipids in Health and Disease·Ning-Yuan ChenShang-Ling Pan
Sep 14, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Qiao Jiang-HuaLiu Zhenzhen

❮ Previous
Next ❯

Citations

Apr 30, 2016·Scientific Reports·Yang XuanDao-Jun Hu
Sep 25, 2017·The Journal of Clinical Hypertension·Boyi YangGuifan Sun
Apr 28, 2018·Journal of the American College of Nutrition·Marina Ramalho RibeiroMaria José de Carvalho Costa
Jul 7, 2020·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·Shou-Fa ZhangYa-Qing Zhang
Apr 27, 2018·Lipids in Health and Disease·Kallur Nava SaraswathyPriyanka Rani Garg
May 27, 2021·BioMed Research International·Chuce DaiXiuhua Yang

❮ Previous
Next ❯

Methods Mentioned

BETA
electrophoresis
genotyping
PCR

Software Mentioned

SPSS

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.