Joint cultivation of human erythroblastoid cells and mouse fibroblasts triggers release of a wide spectrum of cytotoxic factors

Biochemical and Biophysical Research Communications
N V GnuchevS V Razin

Abstract

It has been demonstrated that joint cultivation of human K-562 cells and mouse L-929 cells results in triggering apoptosis in L-929 cells and possibly also in K-562 cells. Analysis of proteins recovered from the culture medium has revealed the presence of three cytotoxic factors including TNF-alpha. This is the first observation of a release of cytotoxic factors by non-lymphoid cells in response to a direct contact with cells of different origin.

Citations

Jun 8, 2000·Journal of Cellular Biochemistry·L P SashchenkoS V Razin
Oct 31, 2003·The Journal of Biological Chemistry·Lidia P SashchenkoGeorgii P Georgiev

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Apoptosis

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