Joint-dependent response to impact and implications for post-traumatic osteoarthritis

Osteoarthritis and Cartilage
K D NovakofskiL A Fortier

Abstract

The prevalence of osteoarthritis (OA) varies between joints. Cartilage in eight different joints was evaluated to elucidate the disparate susceptibilities between joints to post-traumatic OA (PTOA) and provide evidence for joint-specific clinical treatments. The hypothesis was that cartilage in different joints would have varying cell death and anabolic gene expression profiles after injury. Adult equine cartilage explants were harvested from shoulder (SH), elbow (EL), carpal (CA), metacarpophalangeal (MC), patellofemoral (FP), tarsal (TA), metatarsophalangeal (MT), and proximal interphalangeal (PP) joints, and injured by loading with 30 MPa within 1 s. Fractional dissipated energy, cell density, cell death, and gene expression were quantified. PP had the highest fractional dissipated energy (94%, 95% confidence interval [CI] 88 to 101%). Cell density was highest in the superficial zone in all samples, with MC and MT having the highest peak density. Injured samples had significantly increased cell death (13.5%, 95% CI 9.1 to 17.9%) than non-injured samples (6.8%, 95% CI 2.5 to 11.1%, P = 0.016); however, cell death after injury was not significantly different between joints. Gene expression was significantly different between j...Continue Reading

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Citations

Jan 19, 2016·Osteoarthritis and Cartilage·D S Palmer-GreenBrigitte E Scammell
Jul 1, 2016·Orthopedics·Jorge ChahlaCecilia Pascual-Garrido
Jan 17, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Martin H StradnerWinfried B Graninger
Oct 21, 2016·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Michelle L DelcoLisa A Fortier
Feb 14, 2018·Science Translational Medicine·Mitchell C ColemanJames A Martin
Jan 23, 2020·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Bridgette T PealHeidi L Reesink
Jun 17, 2020·Journal of Biomechanical Engineering·Shannon K WalshCorinne R Henak
Jan 2, 2021·Journal of the Mechanical Behavior of Biomedical Materials·Stephany SantosDavid M Pierce

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