Joint effect among p53, CYP1A1, GSTM1 polymorphism combinations and smoking on prostate cancer risk: an exploratory genotype-environment interaction study

Asian Journal of Andrology
Luis A QuiñonesDante D Cáceres

Abstract

To assess the role of several genetic factors in combination with an environmental factor as modulators of prostate cancer risk. We focus on allele variants of low-penetrance genes associated with cell control, the detoxification processes and smoking. In a case-control study we compared people carrying p53cd72 Pro allele, CYP1A1 M1 allele and GSTM1 null genotypes with their prostate cancer risk. The joint risk for smokers carrying Pro* and M1*, Pro* and GSTM1null or GSTM1 null and CYP1A1 M1* variants was significantly higher (odds ratio [OR]: 13.13, 95% confidence interval [CI]: 2.41-71.36; OR: 3.97, 95% CI: 1.13-13.95 and OR: 6.87, 95% CI: 1.68-27.97, respectively) compared with that for the reference group, and for non-smokers was not significant. OR for combinations among p53cd72, GSTM1 and CYP1A1 M1 in smokers were positively and significantly associated with prostate cancer risk compared with non-smokers and compared with the putative lowest risk group (OR: 8.87, 95% CI: 1.25-62.71). Our results suggest that a combination of p53cd72, CYP1A1, GSTM1 alleles and smoking plays a significant role in modified prostate cancer risk on the study population, which means that smokers carrying susceptible genotypes might have a signi...Continue Reading

References

Oct 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·J SeidegårdW R Pearson
Feb 11, 1988·Nucleic Acids Research·S A MillerH F Polesky
Jun 1, 1997·Environmental Health Perspectives·A Hirvonen
Jun 1, 1997·Environmental Health Perspectives·J Seidegård, G Ekström
Apr 18, 2001·International Journal of Cancer. Journal International Du Cancer·A GsurM Micksche
Jun 1, 2001·American Journal of Epidemiology·L D Botto, M J Khoury
Jul 4, 2001·Pharmacogenetics·Z Kote-JaraiUNKNOWN CRC/BPG UK Familial Prostate Cancer Study Collaborators
Mar 19, 2002·Annals of Epidemiology·Steven S Coughlin, Ingrid J Hall
May 29, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·P M FerreiraC Lopes
Jul 29, 2003·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·La Creis R KiddJ A Tangrea

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Citations

Jun 30, 2009·Cancer Causes & Control : CCC·Ke Zu, Edward Giovannucci
Sep 16, 2010·Molecular Biology Reports·Yu ZhuJun-Qing Zhang
Feb 6, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Guangye HanFeng Zhu
Feb 7, 2012·Genetic Testing and Molecular Biomarkers·Yousra SouidenKacem Mahdouani
Sep 22, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tong SunPhilip W Kantoff
Feb 4, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yu LuShan Li
Mar 28, 2008·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Donald T WigleMarie-Elise Parent
Sep 26, 2015·Biomedical Reports·Monika Kmeťová SivoňováDušan Dobrota
Aug 10, 2011·Urologic Oncology·Tin C NgoJoseph C Presti
Sep 6, 2011·Endocrinology and Metabolism Clinics of North America·Shuk-Mei HoYuet-Kin Leung
Jan 1, 2011·Journal of Biomedical Research·Lifeng ZhangNinghan Feng
Mar 11, 2016·Indian Journal of Cancer·A BagN Bag
May 29, 2009·Journal of Surgical Oncology·G X DingL X Hua
Jan 31, 2007·Annals of the New York Academy of Sciences·Shuk-Mei HoIrving Chung
Jul 2, 2010·The Prostate·L Ricks-SantiG M Dunston
Aug 30, 2012·Environmental and Molecular Mutagenesis·Pradeep Singh ChauhanSujala Kapur
Jul 16, 2010·Andrologia·G Tirumala VaniP Pardhanandana Reddy
May 26, 2015·International Braz J Urol : Official Journal of the Brazilian Society of Urology·Mario M de Lima JuniorLaura S Ward
Nov 29, 2015·Technology in Cancer Research & Treatment·Zhong-Yang WangGregor P C Drummen
Oct 16, 2012·Molecular Biology Reports·Huawen LiTaiping He
Jun 18, 2014·Asian Pacific Journal of Cancer Prevention : APJCP·Mohammad Haroon KhanMuhammad Ismail
Apr 28, 2020·Bioscience Reports·Paula EscalanteNelson Miguel Varela
Oct 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei WangXifeng Wu

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