Joint effect of ADARB1 gene, HTR2C gene and stressful life events on suicide attempt risk in patients with major psychiatric disorders

The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry
Jelena KaranovićDušanka Savić Pavićević

Abstract

Adenosine to inosine RNA editing, serotonin 2C receptor (HTR2C), and stressful life events (SLEs) have all been implicated in suicidal behaviour. We examined the main and moderating effects of RNA editing (ADAR, ADARB1) and HTR2C genes, childhood trauma (CT), recent SLEs and psychiatric disorders as contributors to suicide attempt (SA) vulnerability. Study included 165 suicide attempters and 188 suicide non-attempters, all diagnosed with one of major psychiatric disorders. CT and recent SLEs were assessed using Early Trauma Inventory-Self Report and List of Threatening Experiences Questionnaire, respectively. Selected ADAR and ADARB1 tag-variants, and HTR2C rs6318 were pre-screened for association with SA, while generalized linear models and backward selection were applied to identify individual and interacting SA risk factors. ADARB1 rs9983925 and rs4819035 and HTR2C rs6318 were associated with SA. The best minimal model found emotional abuse, recent SLEs, rs9983925 and rs6318 as independent SA risk factors, and general traumas as a factor moderating the effect of psychiatric disorders and emotional abuse. SA vulnerability in psychiatric patients is related to the joint effect of ADARB1 and HTR2C variants, the existing mood di...Continue Reading

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Citations

Feb 2, 2016·Progress in Neuro-psychopharmacology & Biological Psychiatry·Ji Sun Kim, Seung-Hwan Lee
Jul 18, 2016·Journal of the Neurological Sciences·Claudia F GaspariniLyn R Griffiths
Jan 14, 2017·Journal of Neural Transmission·Jelena KaranovićDušanka Savić-Pavićević
Jul 12, 2017·Molecular Psychiatry·P-E LutzG Turecki
Oct 20, 2017·Psychiatric Genetics·Thelma B González-CastroJuan P Sánchez-de la Cruz
Aug 6, 2020·Genes·Alessandro Barbon, Chiara Magri
May 5, 2017·Current Psychiatry Reports·Katherin Sudol, J John Mann
Jul 1, 2017·Human Genetics·Stefan StammRonald B Emeson
Feb 17, 2019·Translational Psychiatry·Fabrice ChimientiDinah Weissmann

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