Joint Effect of Childhood Abuse and Family History of Major Depressive Disorder on Rates of PTSD in People with Personality Disorders.

Depression Research and Treatment
Janine D FloryLarry J Siever

Abstract

Objective. Childhood maltreatment and familial psychopathology both lead to an increased risk of the development of posttraumatic stress disorder (PTSD) in adulthood. While family history of psychopathology has traditionally been viewed as a proxy for genetic predisposition, such pathology can also contribute to a stress-laden environment for the child. Method. Analyses were conducted to evaluate the joint effect of childhood abuse and a family history of major depressive disorder (MDD) on diagnoses of PTSD and MDD in a sample of 225 adults with DSM-IV Axis II disorders. Results. Results showed that the rate of PTSD in the presence of both childhood abuse and MDD family history was almost six-fold (OR = 5.89, P = .001) higher relative to the absence of both factors. In contrast, the rate of MDD in the presence of both factors was associated with a nearly three-fold risk relative to the reference group (OR = 2.75, P = .01). Conclusions. The results from this observational study contribute to a growing understanding of predisposing factors for the development of PTSD and suggest that joint effects of family history of MDD and childhood abuse on PTSD are greater than either factor alone.

References

Jan 1, 1985·The American Journal of Psychiatry·J DavidsonE Hammett
Dec 1, 1995·Archives of General Psychiatry·R C KesslerC B Nelson
Aug 1, 1994·The American Journal of Psychiatry·D P BernsteinJ Ruggiero
Feb 1, 1993·The American Journal of Psychiatry·J D BremnerD S Charney
May 19, 1998·Psychosomatics·B L GreenC Steakley
Jul 22, 1998·Archives of General Psychiatry·N BreslauP Andreski
Oct 28, 1998·Journal of Psychiatric Research·J R DavidsonK M Connor
Jul 13, 1999·Archives of General Psychiatry·J G JohnsonD P Bernstein
Aug 19, 2000·Journal of Personality and Social Psychology·L A ClarkR Ready
Oct 3, 2002·The American Journal of Psychiatry·Murray B SteinW John Livesley
Feb 26, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Jochen Hardt, Michael Rutter
Sep 22, 2007·Annual Review of Psychology·Anthony Charuvastra, Marylene Cloitre
Mar 20, 2008·JAMA : the Journal of the American Medical Association·Elisabeth B BinderKerry J Ressler
May 2, 2008·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·B J MilneT E Moffitt
Dec 9, 2008·Comprehensive Psychiatry·Janine D FloryLarry J Siever
Apr 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Pingxing XieJoel Gelernter
Jun 12, 2010·Journal of Psychiatric Research·Jina PaguraJitender Sareen
Apr 22, 2011·Disease Markers·Rachel YehudaJanine D Flory
May 1, 2011·Development and Psychopathology·Laura C Pratchett, Rachel Yehuda

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.