Apr 22, 2009

Joint effects of common genetic variants on the risk for type 2 diabetes in U.S. men and women of European ancestry

Annals of Internal Medicine
Marilyn C CornelisFrank B Hu

Abstract

Genome-wide association studies have identified novel type 2 diabetes loci, each of which has a modest impact on risk. To examine the joint effects of several type 2 diabetes risk variants and their combination with conventional risk factors on type 2 diabetes risk in 2 prospective cohorts. Nested case-control study. United States. 2809 patients with type 2 diabetes and 3501 healthy control participants of European ancestry from the Health Professionals Follow-up Study and Nurses' Health Study. A genetic risk score (GRS) was calculated on the basis of 10 polymorphisms in 9 loci. After adjustment for age and body mass index (BMI), the odds ratio for type 2 diabetes with each point of GRS, corresponding to 1 risk allele, was 1.19 (95% CI, 1.14 to 1.24) and 1.16 (CI, 1.12 to 1.20) for men and women, respectively. Persons with a BMI of 30 kg/m(2) or greater and a GRS in the highest quintile had an odds ratio of 14.06 (CI, 8.90 to 22.18) compared with persons with a BMI less than 25 kg/m(2) and a GRS in the lowest quintile after adjustment for age and sex. Persons with a positive family history of diabetes and a GRS in the highest quintile had an odds ratio of 9.20 (CI, 5.50 to 15.40) compared with persons without a family history o...Continue Reading

  • References38
  • Citations134

References

  • References38
  • Citations134

Citations

Mentioned in this Paper

Genome-Wide Association Study
Diabetes Mellitus, Non-Insulin-Dependent
European Continental Ancestry Group
Receiver Operating Characteristic
Body Mass Index Procedure
Nested Case-Control Studies
Subgroup A Nepoviruses
Alleles
Genetic Polymorphism
Single Nucleotide Polymorphism

About this Paper

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