Joint Estimation of Activity and Attenuation in Whole-Body TOF PET/MRI Using Constrained Gaussian Mixture Models

IEEE Transactions on Medical Imaging
Abolfazl Mehranian, Habib Zaidi

Abstract

It has recently been shown that the attenuation map can be estimated from time-of-flight (TOF) PET emission data using joint maximum likelihood reconstruction of attenuation and activity (MLAA). In this work, we propose a novel MRI-guided MLAA algorithm for emission-based attenuation correction in whole-body PET/MR imaging. The algorithm imposes MR spatial and CT statistical constraints on the MLAA estimation of attenuation maps using a constrained Gaussian mixture model (GMM) and a Markov random field smoothness prior. Dixon water and fat MR images were segmented into outside air, lung, fat and soft-tissue classes and an MR low-intensity (unknown) class corresponding to air cavities, cortical bone and susceptibility artifacts. The attenuation coefficients over the unknown class were estimated using a mixture of four Gaussians, and those over the known tissue classes using unimodal Gaussians, parameterized over a patient population. To eliminate misclassification of spongy bones with surrounding tissues, and thus include them in the unknown class, we heuristically suppressed fat in water images and also used a co-registered bone probability map. The proposed MLAA-GMM algorithm was compared with the MLAA algorithms proposed by R...Continue Reading

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