Joint fluid leukocyte activation by preformed immune complexes

Inflammation
P ThomsenL E Ericson

Abstract

Acute synovitis was induced in rabbit knee joints by intraarticular injection of preformed bovine serum albumin (BSA) -anti BSA immune complexes (ICs). Polymorphonuclear granulocytes (PMNGs) which had migrated into joints injected with ICs were degranulated and contained ICs as revealed by electron microscopy and were activated as revealed by the measurement of chemiluminescence (CL). In contrast, leukocytes from control joints injected with BSA and normal rabbit serum as well as glycogen-elicited peritoneal leukocytes did not display any morphological changes and did not show CL. Compared to cells from other sources, leukocytes from IC joints showed a decreased CL response when stimulated in vitro with ICs but not with opsonized zymosan, suggesting a stimulus-specific modification of the PMNG responsiveness. Inhibition experiments showed that oxygen radicals and formation of arachidonate metabolites, mainly of the lipoxygenase pathway, were involved in the CL response of the IC-stimulated joint fluid PMNGs. Our observations on morphology, activity, and responsiveness of emigrated cells from the various sources suggest, together with previous observations, that the reaction of leukocytes in IC-induced synovitis consists of an i...Continue Reading

References

Nov 1, 1975·The Journal of Clinical Investigation·I M GoldsteinG Weissmann
Mar 1, 1979·Arthritis and Rheumatism·R A Greenwald, W W Moy
Dec 1, 1978·The Journal of Clinical Investigation·J I GallinE Schiffmann
Jan 1, 1986·Scandinavian Journal of Rheumatology·P ThomsenU Bagge
Jan 1, 1985·Scandinavian Journal of Rheumatology·P ThomsenL E Ericson
May 1, 1974·Arthritis and Rheumatism·N J Zvaifler
Mar 1, 1971·The Journal of Clinical Investigation·P A Ward, N J Zvaifler
Jun 1, 1968·American Journal of Clinical Pathology·D G Palmer
Aug 1, 1984·The Australian Journal of Experimental Biology and Medical Science·K CheungM F Robinson
Sep 1, 1980·The Journal of Clinical Investigation·N J DollJ E Salvaggio
Apr 1, 1980·Arthritis and Rheumatism·R A Greenwald, W W Moy
Apr 1, 1983·Annals of the Rheumatic Diseases·R GaleP J Roberts-Thomson
Jan 1, 1981·International Archives of Allergy and Applied Immunology·L M BjurstenS Ahlstedt

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Citations

Jan 1, 1991·Free Radical Biology & Medicine·C K Chow
Mar 30, 1990·Biochemical and Biophysical Research Communications·P Follin, C Dahlgren

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