Joint injury and osteoarthritis: soluble mediators in the course and treatment of cartilage pathology

Immunotherapy
Marijn RutgersLaura B Creemers

Abstract

Osteoarthritis is a disabling disease of the aging generation, which results in loss of quality of life and increased healthcare costs. Cytokines appear to play an important role in the cartilaginous degeneration characterizing the pathological process. Increasing experience is being gained with cytokine-modulating therapies aimed at interfering with effects of chondrodegradative cytokines in the synovial fluid. Although in vitro and in vivo effectiveness of several of these therapies has been demonstrated, clinical effectiveness remains disputable, which may be related to the low levels of inflammatory cytokines found in osteoarthritic joints. By contrast, directly after joint trauma, which has been shown to predispose to early osteoarthritis, synovial fluid cytokine levels are strongly increased. Cytokine-modulating therapies, however, have hardly been considered for this indication. Increased knowledge of intra-articular soluble mediators correlating with cartilage pathology will lead to further development of cytokine-modulating products and, eventually, to effective inhibition of cartilage degeneration, in both the osteoarthritic as well as injured joints.

References

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Citations

Jul 8, 2015·International Journal of Molecular Sciences·Derek H RosenzweigLisbet Haglund
Dec 17, 2011·Expert Opinion on Biological Therapy·Isabel AndiaNicola Maffulli
Aug 13, 2013·The Journal of Hand Surgery·T TeunisL P van Minnen
Jun 18, 2019·Journal of Research on Adolescence : the Official Journal of the Society for Research on Adolescence·Sam A Hardy, Pamela Ebstyne King

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Methods Mentioned

BETA
lavage
biopsy

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