Joint mapping of quantitative trait Loci for multiple binary characters

Genetics
Chenwu XuShizhong Xu

Abstract

Joint mapping for multiple quantitative traits has shed new light on genetic mapping by pinpointing pleiotropic effects and close linkage. Joint mapping also can improve statistical power of QTL detection. However, such a joint mapping procedure has not been available for discrete traits. Most disease resistance traits are measured as one or more discrete characters. These discrete characters are often correlated. Joint mapping for multiple binary disease traits may provide an opportunity to explore pleiotropic effects and increase the statistical power of detecting disease loci. We develop a maximum-likelihood method for mapping multiple binary traits. We postulate a set of multivariate normal disease liabilities, each contributing to the phenotypic variance of one disease trait. The underlying liabilities are linked to the binary phenotypes through some underlying thresholds. The new method actually maps loci for the variation of multivariate normal liabilities. As a result, we are able to take advantage of existing methods of joint mapping for quantitative traits. We treat the multivariate liabilities as missing values so that an expectation-maximization (EM) algorithm can be applied here. We also extend the method to joint ...Continue Reading

Citations

Jun 8, 2010·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·L X KuY H Chen
Jun 9, 2012·TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik·Zhoufei WangHongsheng Zhang
Jul 30, 2010·Genetics Research·Xiaojuan MiIsmail Dweikat
Apr 24, 2007·Nature Cell Biology·J Robert ManakJoseph S Lipsick
Nov 28, 2012·Statistical Applications in Genetics and Molecular Biology·Chenguang WangRongling Wu
Aug 12, 2008·Genetics·Samprit BanerjeeNengjun Yi
Oct 12, 2012·Genetics and Molecular Biology·Chunfa TongJisen Shi
Apr 11, 2006·PLoS Biology·Avraham E MayoUri Alon
Mar 19, 2014·Animal : an International Journal of Animal Bioscience·J I WellerG R Wiggans
Aug 31, 2013·Briefings in Bioinformatics·R YangYongxin Liu
Jun 24, 2009·Trends in Plant Science·Xuefeng WangBrian A Larkins
Jan 11, 2007·Journal of Evolutionary Biology·Mark W Blows
Aug 2, 2007·American Journal of Human Genetics·Jianfeng LiuHong-Wen Deng
Aug 22, 2006·Nature Reviews. Genetics·Stephen F Chenoweth, Mark W Blows
Aug 17, 2006·Heredity·S Xu, C Xu
Feb 18, 2009·Genetics Research·Chenwu XuShizhong Xu
Jan 9, 2017·G3 : Genes - Genomes - Genetics·Riyan ChengJustin Borevitz

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Hereditary Sensory Autonomic Neuropathy

Hereditary Sensory Autonomic Neuropathies are a group of inherited neurodegenerative disorders characterized clinically by loss of sensation and autonomic dysfunction. Here is the latest research on these neuropathies.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Glut1 Deficiency

Glut1 deficiency, an autosomal dominant, genetic metabolic disorder associated with a deficiency of GLUT1, the protein that transports glucose across the blood brain barrier, is characterized by mental and motor developmental delays and infantile seizures. Follow the latest research on Glut1 deficiency with this feed.

Separation Anxiety

Separation anxiety is a type of anxiety disorder that involves excessive distress and anxiety with separation. This may include separation from places or people to which they have a strong emotional connection with. It often affects children more than adults. Here is the latest research on separation anxiety.

KIF1A Associated Neurological Disorder

KIF1A associated neurological disorder (KAND) is a rare neurodegenerative condition caused by mutations in the KIF1A gene. KAND may present with a wide range and severity of symptoms including stiff or weak leg muscles, low muscle tone, a lack of muscle coordination and balance, and intellectual disability. Find the latest research on KAND here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.