Joint migration of gonadotropin-releasing hormone (GnRH) and neuropeptide Y (NPY) neurons from olfactory placode to central nervous system

Journal of Neurobiology
E M HilalA J Silverman

Abstract

The olfactory epithelium in vertebrates generates the olfactory sensory neurons and several migratory cell types. Prominent among the latter are the gonadotropin-releasing hormone (GnRH) neurons that differentiate within the olfactory epithelium during embryogenesis and migrate along the olfactory nerve to the central nervous system. We initiated studies to characterize additional neuronal phenotypes of olfactory epithelial derivation. Neuropeptide Y (NPY) neurons are functionally related to the reproductive axis, modulating the release of GnRH and directly enhancing GnRH-induced luteinizing hormone (LH) secretion from gonadotrophs. We demonstrate that a population of migratory NPY neurons originates within the olfactory epithelium of the chick. At stage 25, NPY-positive fibers, but not cells, were detected in the epithelium and the nerve. By stages 28-34, NPY neurons and processes were present in the olfactory epithelium, olfactory nerve, and at the junction of the olfactory nerve and forebrain. In these regions the number of NPY neurons increased until stage 30 and then declined as development progressed. Electron microscopic immunocytochemistry confirmed the neuronal phenotype of the NPY-positive cells. The origin and migrat...Continue Reading

References

Jul 11, 1992·Developmental Dynamics : an Official Publication of the American Association of Anatomists·R B NorgrenR Brackenbury
Aug 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·I MerchenthalerA Negro-Vilar
Jun 1, 1991·Journal of Neuroscience Research·M I Chuah, C Au
Mar 9, 1989·Nature·M Schwanzel-Fukuda, D W Pfaff
Oct 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·S WrayH Gainer
Apr 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Tatemoto
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·K Tatemoto
Jul 1, 1993·Experimental Cell Research·V NatafN M Le Douarin
Oct 14, 1994·Brain Research. Developmental Brain Research·S Murakami, Y Arai
Dec 1, 1993·Neuroendocrinology·K A Sullivan, A J Silverman
Feb 1, 1994·Seminars in Cell Biology·A I Farbman
Dec 1, 1993·Developmental Biology·R B Norgren, R Brackenbury

❮ Previous
Next ❯

Citations

Jul 10, 2012·Molecular Neurobiology·Paolo E Forni, Susan Wray
Jul 25, 2003·Biochemical and Biophysical Research Communications·Christopher M MayerDenise D Belsham
Sep 26, 2002·Journal of Chemical Neuroanatomy·B PregoE de Miguel Villegas
Oct 17, 2009·Zoological Science·Takafumi KawaiHeather Eisthen
Jul 9, 2010·Zoological Science·Kiyoshi Terakado
Feb 13, 2001·Endocrine Reviews·E Terasawa, D L Fernandez
Jul 9, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Joseph Wai Keung KamJean-François Cloutier
Apr 23, 1999·Developmental Dynamics : an Official Publication of the American Association of Anatomists·P T Drapkin, A J Silverman
Sep 19, 2014·The Journal of Veterinary Medical Science·Shoko NakamutaIsato Araki
Jul 18, 2001·Microscopy Research and Technique·R K RastogiL Iela
Jan 21, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Prasad S DalviDenise D Belsham
Dec 23, 2020·Open Biology·Guillaume Poncelet, Sebastian M Shimeld
Nov 17, 2020·Frontiers in Physiology·Ed Zandro M TarocPaolo E Forni
Apr 20, 2021·Cellular and Molecular Life Sciences : CMLS·Raghu Ram Katreddi, Paolo E Forni
Jul 20, 2002·Frontiers in Neuroendocrinology·S Wray
Dec 1, 2004·Microscopy Research and Technique·Kathleen E Whitlock
Dec 6, 2005·Neuroscience Letters·Shobha BhargavaDileep Nandkumar Deobagkar

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.