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Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction

PLoS Genetics

Jun 10, 2017

Yiming HuHongyu Zhao

Abstract

Accurate prediction of disease risk based on genetic factors is an important goal in human genetics research and precision medicine. Advanced prediction models will lead to more effective disease prevention and treatment strategies. Despite the identification of thousands of disease-ass...read more

Mentioned in this Paper

Genome-Wide Association Study
EXOSC3 gene
Diabetes Mellitus, Non-Insulin-Dependent
Chromosomes, Human, Pair 1
Treatment Protocols
Meta-Analysis (Publications)
Genome
Coronary Artery Disease
Stratification
GZMK gene
8
59
Paper Details
References
  • References28
  • Citations4
123

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Leveraging functional annotations in genetic risk prediction for human complex diseases

PLoS Computational BiologyJune 9, 2017
Yiming HuHongyu Zhao
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Improved methods for multi-trait fine mapping of pleiotropic risk loci

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© 2020 Meta ULC. All rights reserved

Joint modeling of genetically correlated diseases and functional annotations increases accuracy of polygenic risk prediction

PLoS Genetics

Jun 10, 2017

Yiming HuHongyu Zhao

PMID: 28598966

DOI: 10.1371/journal.pgen.1006836

Abstract

Accurate prediction of disease risk based on genetic factors is an important goal in human genetics research and precision medicine. Advanced prediction models will lead to more effective disease prevention and treatment strategies. Despite the identification of thousands of disease-ass...read more

Mentioned in this Paper

Genome-Wide Association Study
EXOSC3 gene
Diabetes Mellitus, Non-Insulin-Dependent
Chromosomes, Human, Pair 1
Treatment Protocols
Meta-Analysis (Publications)
Genome
Coronary Artery Disease
Stratification
GZMK gene
8
59

Similar Papers Found In These Feeds

Childhood Eating Behaviors

Child eating includes but is not limited to diet patterns, intakes of specific foods or beverages, and eating behaviours. Discover the latest research on childhood eating behaviors here.

Genetics of Autoimmunity

Genome-wide association studies have revealed pathways linked to autoimmune disorders and their pathogenesis. Discover the latest research on the Genetics of Autoimmunity here.

Related Papers

PLoS Computational Biology

Leveraging functional annotations in genetic risk prediction for human complex diseases

PLoS Computational BiologyJune 9, 2017
Yiming HuHongyu Zhao
Bioinformatics

Improved methods for multi-trait fine mapping of pleiotropic risk loci

BioinformaticsSeptember 25, 2016
Gleb KichaevBogdan Pasaniuc
Paper Details
References
  • References28
  • Citations4
123
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