Joint modeling of longitudinal ordinal data and competing risks survival times and analysis of the NINDS rt-PA stroke trial.

Statistics in Medicine
Ning LiJeffrey Saver

Abstract

Existing joint models for longitudinal and survival data are not applicable for longitudinal ordinal outcomes with possible non-ignorable missing values caused by multiple reasons. We propose a joint model for longitudinal ordinal measurements and competing risks failure time data, in which a partial proportional odds model for the longitudinal ordinal outcome is linked to the event times by latent random variables. At the survival endpoint, our model adopts the competing risks framework to model multiple failure types at the same time. The partial proportional odds model, as an extension of the popular proportional odds model for ordinal outcomes, is more flexible and at the same time provides a tool to test the proportional odds assumption. We use a likelihood approach and derive an EM algorithm to obtain the maximum likelihood estimates of the parameters. We further show that all the parameters at the survival endpoint are identifiable from the data. Our joint model enables one to make inference for both the longitudinal ordinal outcome and the failure times simultaneously. In addition, the inference at the longitudinal endpoint is adjusted for possible non-ignorable missing data caused by the failure times. We apply the met...Continue Reading

References

Jan 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·A Tsiatis
Dec 14, 1995·The New England Journal of Medicine·UNKNOWN National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Aug 23, 2003·Biostatistics·R HendersonA Dobson

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Citations

Jul 31, 2010·BMC Medical Research Methodology·Emmanuelle Deslandes, Sylvie Chevret
Jan 14, 2017·JMIR MHealth and UHealth·Emily A SchererJohn M Kane
Mar 17, 2019·American Journal of Epidemiology·Susan M ShortreedJennifer C Nelson
Mar 19, 2016·Statistical Methods in Medical Research·Carmen ArmeroSilvia Agustí
Dec 18, 2014·Journal of Epidemiology and Community Health·Maryam KarimiGrégoire Rey
Nov 5, 2016·Statistics in Medicine·C ArmeroM Baré
Feb 2, 2018·The International Journal of Biostatistics·Graeme L HickeyRuwanthi Kolamunnage-Dona
Nov 26, 2020·Lifetime Data Analysis·Khurshid AlamAbdus Sattar
May 29, 2012·Statistical Methods in Medical Research·Chi-hong TsengGang Li
Jun 28, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Stacia M DesantisViswanathan Ramakrishnan
Oct 24, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Fraser C GoldieUNKNOWN VISTA Collaboration
Mar 20, 2012·Stroke; a Journal of Cerebral Circulation·Philip M W BathUNKNOWN European Stroke Organisation Outcomes Working Group

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