Joint production of IL-22 participates in the initial phase of antigen-induced arthritis through IL-1β production

Arthritis Research & Therapy
Larissa G PintoFernando Q Cunha

Abstract

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by neutrophil articular infiltration, joint pain and the progressive destruction of cartilage and bone. IL-22 is a key effector molecule that plays a critical role in autoimmune diseases. However, the function of IL-22 in the pathogenesis of RA remains controversial. In this study, we investigated the role of IL-22 in the early phase of antigen-induced arthritis (AIA) in mice. AIA was induced in C57BL/6, IL-22(-/-), ASC(-/-) and IL-1R1(-/-) immunized mice challenged intra-articularly with methylated bovine serum albumin (mBSA). Expression of IL-22 in synovial membranes was determined by RT-PCR. Articular hypernociception was evaluated using an electronic von Frey. Neutrophil recruitment and histopathological analyses were assessed in inflamed knee joint. Joint levels of inflammatory mediators and mBSA-specific IgG concentration in the serum were measured by ELISA. The IL-22 mRNA expression and protein levels in synovial tissue were increased during the onset of AIA. In addition, pharmacological inhibition (anti-IL-22 antibody) and genetic deficiency (IL-22(-/-) mice) reduced articular pain and neutrophil migration in arthritic mice. Consistent with these fi...Continue Reading

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Citations

Mar 9, 2017·Arthritis Research & Therapy·Raphael S PeresJose C Alves-Filho
Oct 3, 2017·Rheumatology·Ramin RaoofNiels Eijkelkamp
Jun 11, 2020·Biomolecules·Morgana K B PradoLúcia H Faccioli
Oct 3, 2020·Mediators of Inflammation·Yanting CaoYiqing Yin
Jan 10, 2019·Journal of Immunology Research·Weiqian ChenJin Lin
Feb 2, 2020·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Germanna M BarbosaTania F Salvini
Jan 8, 2021·Seminars in Arthritis and Rheumatism·Lee S SimonFrank Porreca
Dec 29, 2020·Rheumatology·Ayda Henriques SchneiderFernando Queiroz Cunha
Mar 19, 2021·Journal of Cellular and Molecular Medicine·Ramzi NehmarPhilippe Georgel
Oct 20, 2020·Frontiers in Immunology·Xunyao Wu

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA
PCR

Software Mentioned

GraphPad Prism
GraphPad

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